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- W3080776050 abstract "Arsinothricin [AST (1)], a new broad-spectrum organoarsenical antibiotic, is a nonproteinogenic analogue of glutamate that effectively inhibits glutamine synthetase. We report the chemical synthesis of an intermediate in the pathway to 1, hydroxyarsinothricin [AST-OH (2)], which can be converted to 1 by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. This is the first report of semisynthesis of 1, providing a source of this novel antibiotic that will be required for future clinical trials." @default.
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- W3080776050 date "2020-08-24" @default.
- W3080776050 modified "2023-10-18" @default.
- W3080776050 title "Semisynthesis of the Organoarsenical Antibiotic Arsinothricin" @default.
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- W3080776050 doi "https://doi.org/10.1021/acs.jnatprod.0c00522" @default.
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