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• W3080779375 startingPage "1008" @default.
• W3080779375 abstract "Cerebral hernia in crested chicken has been characterized as the protrusion of cerebral hemispheres into the unsealed skull for hundreds of years, since Charles Darwin. The development of deformed forebrain (telencephalon) of cerebral hernia remains largely unknown. Here, the unsealed frontal skull combined with misplaced sphenoid bone was observed and potentially associated with brain protuberance. The shifted pallidum, elongated hippocampus, expanded mesopallium and nidopallium, and reduced hyperpallium were observed in seven regions of the malformed telencephalon. The neurons were detected with nuclear pyknosis and decreased density. Astrocytes showed uneven distribution and disordered protuberances in hyperpallium and hippocampus. Transcriptome analyses of chicken telencephalon (cerebral hernia vs. control) revealed 547 differentially expressed genes (DEGs), mainly related to nervous system development, and immune system processes, including astrocyte marker gene GFAP, and neuron and astrocyte developmental gene S100A6. The upregulation of GFAP and S100A6 genes in abnormal telencephalon was correlated with reduced DNA methylation levels in the promoter regions. The morphological, cellular, and molecular variations in the shape, regional specification, and cellular states of malformed telencephalon potentially participate in brain plasticity and previously reported behavior changes. Chickens with cerebral hernia might be an interesting and valuable disease model to further explore the recognition, diagnosis, and therapy of cerebral hernia development of crested chickens and other species." @default.
• W3080779375 created "2020-09-01" @default.
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• W3080779375 date "2020-08-27" @default.
• W3080779375 modified "2023-10-16" @default.
• W3080779375 title "Deciphering the Forebrain Disorder in a Chicken Model of Cerebral Hernia" @default.
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• W3080779375 doi "https://doi.org/10.3390/genes11091008" @default.
• W3080779375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564858" @default.
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