Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080796635> ?p ?o ?g. }
- W3080796635 endingPage "166" @default.
- W3080796635 startingPage "159" @default.
- W3080796635 abstract "Adenoviral vectors expressing wild-type p53 (Ad-p53) induce apoptosis in different types of cancer cells. The therapeutic utility of Ad-p53 is now being evaluated in prostate-cancer patients. Bcl-2 is frequently expressed by prostate-cancer cells and has previously been shown to inhibit p53-mediated cell death following genotoxic stress. We studied the impact of bcl-2 on Ad-p53–induced cell death in human prostate-cancer cells. Human prostate-cancer cell lines LNCaP (p53 wt) and PC3 (p53 mut) were stably transfected with bcl-2. After p53 transduction, cell viability, apoptosis induction and modulation of specific apoptosis-regulatory proteins were assessed. LNCaP vector control and bcl-2–expressing cells underwent similar decreases in viability associated with apoptosis induction following Ad-p53 infection. Increased bcl-2 expression provided significant protection to PC3 cells transduced with Ad-p53. These findings are correlated with modulations in bax, bcl-2, bcl-xL and p21 protein levels. These data suggest that Ad-p53 may be useful in the treatment of some prostate cancers. © 2001 Wiley-Liss, Inc." @default.
- W3080796635 created "2020-09-01" @default.
- W3080796635 creator A5008820123 @default.
- W3080796635 creator A5012824310 @default.
- W3080796635 creator A5015426068 @default.
- W3080796635 creator A5020667709 @default.
- W3080796635 creator A5027152610 @default.
- W3080796635 creator A5029814279 @default.
- W3080796635 creator A5078170493 @default.
- W3080796635 creator A5089392140 @default.
- W3080796635 date "2000-12-11" @default.
- W3080796635 modified "2023-10-06" @default.
- W3080796635 title "Molecular determinants of cell death induction following adenovirus-mediated gene transfer of wild-type p53 in prostate cancer cells" @default.
- W3080796635 cites W161930446 @default.
- W3080796635 cites W1850446337 @default.
- W3080796635 cites W1975618936 @default.
- W3080796635 cites W1979319210 @default.
- W3080796635 cites W1981747790 @default.
- W3080796635 cites W1990406980 @default.
- W3080796635 cites W1990743609 @default.
- W3080796635 cites W2000127507 @default.
- W3080796635 cites W2003694128 @default.
- W3080796635 cites W2012939857 @default.
- W3080796635 cites W2013023284 @default.
- W3080796635 cites W2018685233 @default.
- W3080796635 cites W2021544813 @default.
- W3080796635 cites W2021875656 @default.
- W3080796635 cites W2027008846 @default.
- W3080796635 cites W2034092995 @default.
- W3080796635 cites W2038809726 @default.
- W3080796635 cites W2039554573 @default.
- W3080796635 cites W2044296969 @default.
- W3080796635 cites W2045086385 @default.
- W3080796635 cites W2048743150 @default.
- W3080796635 cites W2051589855 @default.
- W3080796635 cites W2053648381 @default.
- W3080796635 cites W2057010527 @default.
- W3080796635 cites W2058561774 @default.
- W3080796635 cites W2058917998 @default.
- W3080796635 cites W2061042441 @default.
- W3080796635 cites W2062278789 @default.
- W3080796635 cites W2065968028 @default.
- W3080796635 cites W2066707764 @default.
- W3080796635 cites W2071037802 @default.
- W3080796635 cites W2074114480 @default.
- W3080796635 cites W2076940668 @default.
- W3080796635 cites W2081290278 @default.
- W3080796635 cites W2092537625 @default.
- W3080796635 cites W2109327605 @default.
- W3080796635 cites W2112248146 @default.
- W3080796635 cites W2114473415 @default.
- W3080796635 cites W2120435603 @default.
- W3080796635 cites W2121421904 @default.
- W3080796635 cites W2134979684 @default.
- W3080796635 cites W2168084973 @default.
- W3080796635 cites W2171483351 @default.
- W3080796635 cites W2244995601 @default.
- W3080796635 cites W2328799185 @default.
- W3080796635 doi "https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1026>3.0.co;2-n" @default.
- W3080796635 hasPublicationYear "2000" @default.
- W3080796635 type Work @default.
- W3080796635 sameAs 3080796635 @default.
- W3080796635 citedByCount "2" @default.
- W3080796635 countsByYear W30807966352020 @default.
- W3080796635 crossrefType "journal-article" @default.
- W3080796635 hasAuthorship W3080796635A5008820123 @default.
- W3080796635 hasAuthorship W3080796635A5012824310 @default.
- W3080796635 hasAuthorship W3080796635A5015426068 @default.
- W3080796635 hasAuthorship W3080796635A5020667709 @default.
- W3080796635 hasAuthorship W3080796635A5027152610 @default.
- W3080796635 hasAuthorship W3080796635A5029814279 @default.
- W3080796635 hasAuthorship W3080796635A5078170493 @default.
- W3080796635 hasAuthorship W3080796635A5089392140 @default.
- W3080796635 hasBestOaLocation W30807966351 @default.
- W3080796635 hasConcept C121608353 @default.
- W3080796635 hasConcept C190283241 @default.
- W3080796635 hasConcept C2776235491 @default.
- W3080796635 hasConcept C2779723316 @default.
- W3080796635 hasConcept C2780192828 @default.
- W3080796635 hasConcept C31573885 @default.
- W3080796635 hasConcept C502942594 @default.
- W3080796635 hasConcept C53227056 @default.
- W3080796635 hasConcept C54009773 @default.
- W3080796635 hasConcept C54355233 @default.
- W3080796635 hasConcept C81885089 @default.
- W3080796635 hasConcept C86803240 @default.
- W3080796635 hasConcept C96232424 @default.
- W3080796635 hasConceptScore W3080796635C121608353 @default.
- W3080796635 hasConceptScore W3080796635C190283241 @default.
- W3080796635 hasConceptScore W3080796635C2776235491 @default.
- W3080796635 hasConceptScore W3080796635C2779723316 @default.
- W3080796635 hasConceptScore W3080796635C2780192828 @default.
- W3080796635 hasConceptScore W3080796635C31573885 @default.
- W3080796635 hasConceptScore W3080796635C502942594 @default.
- W3080796635 hasConceptScore W3080796635C53227056 @default.
- W3080796635 hasConceptScore W3080796635C54009773 @default.
- W3080796635 hasConceptScore W3080796635C54355233 @default.
- W3080796635 hasConceptScore W3080796635C81885089 @default.