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- W3080821392 abstract "Citation: Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation. N Engl J Med 2019; 380:1509–1524. DOI: 10.1056/NEJMoa1817083Patient Population:. Adult patients with atrial fibrillation (AF) who were indicated for use of oral anticoagulation who developed an acute coronary syndrome (ACS) event or had undergone percutaneous coronary intervention (PCI) in the last 14 days, with planned use of a P2Y12 inhibitor for at least six months. Patients with severe renal insufficiency (defined as creatinine clearance less than 30 ml/min or serum creatinine greater than 2.5 mg/dL) and patients who were using anticoagulation for other conditions, such as prosthetic valves or venous thromboembolism, were excluded from the study.Intervention:. The trial was a two-by-two factorial design comparing apixaban with a vitamin K antagonist (VKA) and comparing aspirin (ASA) with a placebo. For the first factorial comparison, a total of 2,306 patients were randomized to receive apixaban. Of these randomized patients, 2,290 patients received at least one dose of apixaban. As for the second factorial comparison, 2,307 patients were randomized to receive ASA. Of these randomized patients, 2,277 patients received at least one dose of ASA.Comparison:. A total of 2,308 patients were randomized to receive VKA, and 2,259 patients received at least one dose of VKA. Those subjects had the dose adjusted to reach a target international normalized ratio (INR) within a range of 2.0 to 3.0. As for the second factorial comparison, a placebo was assigned to 2,307 patients. Of these patients, 2,279 had received at least one dose of the placebo.Outcome:. The primary outcome was a composite of major and clinically relevant nonmajor bleeding defined by the International Society on Thrombosis and Hemostasis with a follow-up period of six months. A secondary outcome evaluated was a composite of all-cause death and all-cause hospitalization, as well as a composite of death or ischemic events." @default.
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- W3080821392 date "2020-04-13" @default.
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- W3080821392 title "Critical Appraisal of the AUGUSTUS Trial" @default.
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- W3080821392 doi "https://doi.org/10.37901/jcphp19-00009" @default.
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