FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080823035> ?p ?o ?g. }

• W3080823035 endingPage "e202000654" @default.
• W3080823035 startingPage "e202000654" @default.
• W3080823035 abstract "The activated B-cell (ABC) to plasmablast transition encompasses the cusp of antibody-secreting cell (ASC) differentiation. We explore this transition with integrated analysis in human cells, focusing on changes that follow removal from CD40-mediated signals. Within hours of input signal loss, cell growth programs shift toward enhanced proliferation, accompanied by ER-stress response, and up-regulation of ASC features. Clustering of genomic occupancy for IRF4, BLIMP1, XBP1, and CTCF with histone marks identifies a dichotomy: XBP1 and IRF4 link to induced but not repressed gene modules in plasmablasts, whereas BLIMP1 links to modules of ABC genes that are repressed, but not to activated genes. Between ABC and plasmablast states, IRF4 shifts away from AP1/IRF composite elements while maintaining occupancy at IRF and ETS/IRF elements. This parallels the loss of BATF expression, which is identified as a potential BLIMP1 target. In plasmablasts, IRF4 acquires an association with CTCF, a feature maintained in plasma cell myeloma lines. Thus, shifting occupancy links IRF4 to both ABC and ASC gene expression, whereas BLIMP1 occupancy links to repression of the activation state." @default.
• W3080823035 created "2020-09-01" @default.
• W3080823035 creator A5014132442 @default.
• W3080823035 creator A5022334281 @default.
• W3080823035 creator A5025070494 @default.
• W3080823035 creator A5040412404 @default.
• W3080823035 creator A5055527227 @default.
• W3080823035 creator A5056726870 @default.
• W3080823035 date "2020-08-25" @default.
• W3080823035 modified "2023-09-27" @default.
• W3080823035 title "A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition" @default.
• W3080823035 cites W1484972278 @default.
• W3080823035 cites W1970400561 @default.
• W3080823035 cites W1970854602 @default.
• W3080823035 cites W1973562447 @default.
• W3080823035 cites W1975213528 @default.
• W3080823035 cites W1977163745 @default.
• W3080823035 cites W1979733074 @default.
• W3080823035 cites W1981403111 @default.
• W3080823035 cites W1988548899 @default.
• W3080823035 cites W1991300427 @default.
• W3080823035 cites W2001042507 @default.
• W3080823035 cites W2009445020 @default.
• W3080823035 cites W2014677321 @default.
• W3080823035 cites W2025434551 @default.
• W3080823035 cites W2025846979 @default.
• W3080823035 cites W2026549568 @default.
• W3080823035 cites W2028330103 @default.
• W3080823035 cites W2035238198 @default.
• W3080823035 cites W2043332368 @default.
• W3080823035 cites W2045067923 @default.
• W3080823035 cites W2045389135 @default.
• W3080823035 cites W2046517086 @default.
• W3080823035 cites W2053723133 @default.
• W3080823035 cites W2055192078 @default.
• W3080823035 cites W2062141110 @default.
• W3080823035 cites W2065125513 @default.
• W3080823035 cites W2065391646 @default.
• W3080823035 cites W2066555099 @default.
• W3080823035 cites W2068140873 @default.
• W3080823035 cites W2071959000 @default.
• W3080823035 cites W2082672818 @default.
• W3080823035 cites W2090510808 @default.
• W3080823035 cites W2095924801 @default.
• W3080823035 cites W2096083625 @default.
• W3080823035 cites W2105066639 @default.
• W3080823035 cites W2105454781 @default.
• W3080823035 cites W2109897790 @default.
• W3080823035 cites W2111353388 @default.
• W3080823035 cites W2111480476 @default.
• W3080823035 cites W2111500154 @default.
• W3080823035 cites W2113142075 @default.
• W3080823035 cites W2113935225 @default.
• W3080823035 cites W2121315642 @default.
• W3080823035 cites W2121496836 @default.
• W3080823035 cites W2122348846 @default.
• W3080823035 cites W2130410032 @default.
• W3080823035 cites W2133322087 @default.
• W3080823035 cites W2136392251 @default.
• W3080823035 cites W2139728074 @default.
• W3080823035 cites W2141668423 @default.
• W3080823035 cites W2141741074 @default.
• W3080823035 cites W2142766411 @default.
• W3080823035 cites W2143470489 @default.
• W3080823035 cites W2145221987 @default.
• W3080823035 cites W2150382709 @default.
• W3080823035 cites W2162419299 @default.
• W3080823035 cites W2169493398 @default.
• W3080823035 cites W2170136419 @default.
• W3080823035 cites W2170551349 @default.
• W3080823035 cites W2171808845 @default.
• W3080823035 cites W2260507520 @default.
• W3080823035 cites W2266921405 @default.
• W3080823035 cites W2593538080 @default.
• W3080823035 cites W2594104586 @default.
• W3080823035 cites W2755564243 @default.
• W3080823035 cites W2775911035 @default.
• W3080823035 cites W2787240390 @default.
• W3080823035 cites W2799828163 @default.
• W3080823035 cites W2889984066 @default.
• W3080823035 cites W2891353862 @default.
• W3080823035 cites W2920200802 @default.
• W3080823035 cites W2936294188 @default.
• W3080823035 cites W2944018172 @default.
• W3080823035 cites W2950500116 @default.
• W3080823035 cites W2950981394 @default.
• W3080823035 cites W2962936545 @default.
• W3080823035 cites W3043633702 @default.
• W3080823035 doi "https://doi.org/10.26508/lsa.202000654" @default.
• W3080823035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7471511" @default.
• W3080823035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32843533" @default.
• W3080823035 hasPublicationYear "2020" @default.
• W3080823035 type Work @default.
• W3080823035 sameAs 3080823035 @default.
• W3080823035 citedByCount "4" @default.
• W3080823035 countsByYear W30808230352021 @default.
• W3080823035 countsByYear W30808230352023 @default.
• W3080823035 crossrefType "journal-article" @default.

• next