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- W3080856886 abstract "Signaling pathways mediated by corticotropin-releasing factor and its receptor 1 (CRF1) play a central role in stress responses. Dysfunction of the CRF system has been associated with neuropsychiatric disorders. However, dynamic changes in the CRF system during brain development and aging are not well investigated. In this study, we characterized CRF1, CRF, and corticotropin-releasing factor binding protein (CRFBP) expression in different brain regions in both male and female C57BL/6J mice from 1 to 18 months of age under basal conditions as well as after an acute 2-hr-restraint stress. We found that CRF and CRF1 levels tended to increase in the hippocampus and hypothalamus, and to decrease in the prefrontal cortex with aging, especially at 18 months of age, whereas CRFBP expression followed an opposite direction in these brain areas. We also observed area-specific sex differences in the expression of these three proteins. For example, CRF expression was lower in females than in males in all the brain regions examined except the prefrontal cortex. After acute stress, CRF and CRF1 were up-regulated at 1, 6, and 12 months of age, and down-regulated at 18 months of age. Females showed more robust changes compared to males of the same age. CRFBP expression either decreased or remained unchanged in most of the brain areas following acute stress. Our findings suggest that brain CRF1, CRF, and CRFBP expression changes dynamically across the lifespan and under stress condition in a sex- and regional-specific manner. Sex differences in the CRF system in response to stress may contribute to the etiology of stress-related neuropsychiatric disorders." @default.
- W3080856886 created "2020-09-01" @default.
- W3080856886 creator A5001702447 @default.
- W3080856886 creator A5031972158 @default.
- W3080856886 creator A5044115597 @default.
- W3080856886 creator A5048411184 @default.
- W3080856886 date "2020-09-17" @default.
- W3080856886 modified "2023-10-18" @default.
- W3080856886 title "Sex differences in CRF1, CRF, and CRFBP expression in C57BL/6J mouse brain across the lifespan and in response to acute stress" @default.
- W3080856886 cites W1516855691 @default.
- W3080856886 cites W1547358456 @default.
- W3080856886 cites W1583493847 @default.
- W3080856886 cites W1961990310 @default.
- W3080856886 cites W1968768036 @default.
- W3080856886 cites W1969909017 @default.
- W3080856886 cites W1971871622 @default.
- W3080856886 cites W1986576876 @default.
- W3080856886 cites W1989767966 @default.
- W3080856886 cites W1989868932 @default.
- W3080856886 cites W1990168204 @default.
- W3080856886 cites W1993517945 @default.
- W3080856886 cites W1994134409 @default.
- W3080856886 cites W1997558473 @default.
- W3080856886 cites W1998821779 @default.
- W3080856886 cites W2000982388 @default.
- W3080856886 cites W2004954728 @default.
- W3080856886 cites W2009718363 @default.
- W3080856886 cites W2009894125 @default.
- W3080856886 cites W2012416101 @default.
- W3080856886 cites W2017168736 @default.
- W3080856886 cites W2019500639 @default.
- W3080856886 cites W2030063067 @default.
- W3080856886 cites W2043525975 @default.
- W3080856886 cites W2043873053 @default.
- W3080856886 cites W2053046812 @default.
- W3080856886 cites W2053152793 @default.
- W3080856886 cites W2058410379 @default.
- W3080856886 cites W2060644077 @default.
- W3080856886 cites W2064960891 @default.
- W3080856886 cites W2065286189 @default.
- W3080856886 cites W2067632849 @default.
- W3080856886 cites W2071271451 @default.
- W3080856886 cites W2071635877 @default.
- W3080856886 cites W2072261329 @default.
- W3080856886 cites W2084255057 @default.
- W3080856886 cites W2097624440 @default.
- W3080856886 cites W2107137029 @default.
- W3080856886 cites W2110748165 @default.
- W3080856886 cites W2111989793 @default.
- W3080856886 cites W2116629441 @default.
- W3080856886 cites W2120430663 @default.
- W3080856886 cites W2127552596 @default.
- W3080856886 cites W2130632774 @default.
- W3080856886 cites W2134120617 @default.
- W3080856886 cites W2136709982 @default.
- W3080856886 cites W2137296158 @default.
- W3080856886 cites W2149348857 @default.
- W3080856886 cites W2156753743 @default.
- W3080856886 cites W2158846262 @default.
- W3080856886 cites W2159178030 @default.
- W3080856886 cites W2159285109 @default.
- W3080856886 cites W2176880930 @default.
- W3080856886 cites W2219544230 @default.
- W3080856886 cites W2271649262 @default.
- W3080856886 cites W2320349682 @default.
- W3080856886 cites W2326431615 @default.
- W3080856886 cites W2327790265 @default.
- W3080856886 cites W2414287196 @default.
- W3080856886 cites W2419249579 @default.
- W3080856886 cites W2538785446 @default.
- W3080856886 cites W2582627625 @default.
- W3080856886 cites W2593254042 @default.
- W3080856886 cites W2708473318 @default.
- W3080856886 cites W2748566999 @default.
- W3080856886 cites W2749780304 @default.
- W3080856886 cites W2765412856 @default.
- W3080856886 cites W2791198016 @default.
- W3080856886 cites W2793612613 @default.
- W3080856886 cites W2801203507 @default.
- W3080856886 cites W2887873477 @default.
- W3080856886 cites W2902341990 @default.
- W3080856886 cites W2914973958 @default.
- W3080856886 cites W2942918775 @default.
- W3080856886 cites W2986182493 @default.
- W3080856886 cites W3008371933 @default.
- W3080856886 cites W4210987525 @default.
- W3080856886 doi "https://doi.org/10.1111/jnc.15157" @default.
- W3080856886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32813270" @default.
- W3080856886 hasPublicationYear "2020" @default.
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