FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080941856> ?p ?o ?g. }

• W3080941856 abstract "Abstract BRCA1 germline mutation carriers are predisposed to breast cancers. Epigenomic regulations have been known to strongly interact with genetic variations and potentially mediate biochemical cascades involved in tumorigenesis. Due to the cell-type specificity of epigenomic features, profiling of individual cell types is critical for understanding the molecular events in various cellular compartments within complex breast tissue. Here we report cell-type-specific profiling of genome-wide histone modifications including H3K27ac and H3K4me3 in basal, luminal progenitor, mature luminal, and stromal cells extracted from pre-cancer BRCA1 mutation carriers and non-carriers, conducted using a low-input technology that we developed. We discover that basal and stromal cells present the most extensive epigenomic differences between mutation carriers ( BRCA1 mut /+ ) and non-carriers ( BRCA1 +/+ ) while luminal progenitor and mature luminal cells are relatively unchanged with the mutation. Furthermore, the epigenomic changes in basal cells due to BRCA1 mutation appear to facilitate their transformation into luminal progenitor cells. Our findings shed light on the pre-cancer epigenomic dynamics due to BRCA1 mutation and how they may contribute to eventual development of predominantly basal-like breast cancer." @default.
• W3080941856 created "2020-09-01" @default.
• W3080941856 creator A5022265671 @default.
• W3080941856 creator A5039556188 @default.
• W3080941856 creator A5049924861 @default.
• W3080941856 creator A5059995356 @default.
• W3080941856 date "2020-08-24" @default.
• W3080941856 modified "2023-10-17" @default.
• W3080941856 title "Cell-type-specific epigenomic variations associated with BRCA1 mutation in pre-cancer human breast tissues" @default.
• W3080941856 cites W1029697775 @default.
• W3080941856 cites W1566531598 @default.
• W3080941856 cites W1572075318 @default.
• W3080941856 cites W1968665517 @default.
• W3080941856 cites W1970469121 @default.
• W3080941856 cites W1974597417 @default.
• W3080941856 cites W1976739900 @default.
• W3080941856 cites W1979594866 @default.
• W3080941856 cites W1981030303 @default.
• W3080941856 cites W1982224118 @default.
• W3080941856 cites W1990153910 @default.
• W3080941856 cites W1994354807 @default.
• W3080941856 cites W1996208544 @default.
• W3080941856 cites W2000115025 @default.
• W3080941856 cites W2001144553 @default.
• W3080941856 cites W2011214996 @default.
• W3080941856 cites W2014677321 @default.
• W3080941856 cites W2015416439 @default.
• W3080941856 cites W2023342647 @default.
• W3080941856 cites W2029530775 @default.
• W3080941856 cites W2031941215 @default.
• W3080941856 cites W2036367876 @default.
• W3080941856 cites W2044713924 @default.
• W3080941856 cites W2060792241 @default.
• W3080941856 cites W2061672761 @default.
• W3080941856 cites W2074411498 @default.
• W3080941856 cites W2074581450 @default.
• W3080941856 cites W2076154138 @default.
• W3080941856 cites W2077986050 @default.
• W3080941856 cites W2082645493 @default.
• W3080941856 cites W2085042277 @default.
• W3080941856 cites W2091303550 @default.
• W3080941856 cites W2096027508 @default.
• W3080941856 cites W2097083248 @default.
• W3080941856 cites W2102161352 @default.
• W3080941856 cites W2102904139 @default.
• W3080941856 cites W2104116111 @default.
• W3080941856 cites W2115125074 @default.
• W3080941856 cites W2118498634 @default.
• W3080941856 cites W2118567824 @default.
• W3080941856 cites W2120100277 @default.
• W3080941856 cites W2120512382 @default.
• W3080941856 cites W2121691013 @default.
• W3080941856 cites W2124514674 @default.
• W3080941856 cites W2124985265 @default.
• W3080941856 cites W2137162822 @default.
• W3080941856 cites W2138733479 @default.
• W3080941856 cites W2140930673 @default.
• W3080941856 cites W2145539398 @default.
• W3080941856 cites W2153864725 @default.
• W3080941856 cites W2163709149 @default.
• W3080941856 cites W2169640176 @default.
• W3080941856 cites W2169966147 @default.
• W3080941856 cites W2170830174 @default.
• W3080941856 cites W2171808845 @default.
• W3080941856 cites W2178061693 @default.
• W3080941856 cites W2180334285 @default.
• W3080941856 cites W2257615058 @default.
• W3080941856 cites W2292067704 @default.
• W3080941856 cites W2293001166 @default.
• W3080941856 cites W2342925598 @default.
• W3080941856 cites W2414891331 @default.
• W3080941856 cites W2528899297 @default.
• W3080941856 cites W2550936880 @default.
• W3080941856 cites W2567206156 @default.
• W3080941856 cites W2593633772 @default.
• W3080941856 cites W2616974521 @default.
• W3080941856 cites W2627871710 @default.
• W3080941856 cites W2715937868 @default.
• W3080941856 cites W2724535511 @default.
• W3080941856 cites W2749774911 @default.
• W3080941856 cites W2768147024 @default.
• W3080941856 cites W2769379242 @default.
• W3080941856 cites W2800916947 @default.
• W3080941856 cites W2802269419 @default.
• W3080941856 cites W2810826647 @default.
• W3080941856 cites W2889146372 @default.
• W3080941856 cites W2892728538 @default.
• W3080941856 cites W2900044275 @default.
• W3080941856 cites W2901303766 @default.
• W3080941856 cites W2941302576 @default.
• W3080941856 cites W2941358929 @default.
• W3080941856 cites W2953622121 @default.
• W3080941856 cites W2979238646 @default.
• W3080941856 cites W2982495058 @default.
• W3080941856 cites W2991343932 @default.
• W3080941856 cites W4231356616 @default.
• W3080941856 cites W4242289937 @default.
• W3080941856 cites W48270215 @default.
• W3080941856 doi "https://doi.org/10.1101/2020.08.24.265199" @default.
• W3080941856 hasPublicationYear "2020" @default.

• next