Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080946997> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3080946997 endingPage "1" @default.
- W3080946997 startingPage "1" @default.
- W3080946997 abstract "Drug repositioning is an important approach for drug discovery. Computational drug repositioning approaches typically use a gene signature to represent a particular disease and connect the gene signature with drug perturbation profiles. Although disease samples, especially from cancer, may be heterogeneous, most existing methods consider them as a homogeneous set to identify differentially expressed genes (DEGs)for further determining a gene signature. As a result, some genes that should be in a gene signature may be averaged off. In this study, we propose a new framework to identify gene signatures for cancer drug repositioning based on sample clustering (GS4CDRSC). GS4CDRSC first groups samples into several clusters based on their gene expression profiles. Second, an existing method is applied to the samples in each cluster for generating a list of DEGs. Then a weighting approach is used to identify an intergrated gene signature from all the lists of DEGs. The integrated gene signature is used to connect with drug perturbation profiles in the Connectivity Map (CMap)database to generate a list of drug candidates. GS4CDRSC has been tested with several cancer datasets and existing methods. The computational results show that GS4CDRSC outperforms those methods without the sample clustering and weighting approaches in terms of both number and rate of predicted known drugs for specific cancers." @default.
- W3080946997 created "2020-09-01" @default.
- W3080946997 creator A5023697352 @default.
- W3080946997 creator A5031510017 @default.
- W3080946997 creator A5058768577 @default.
- W3080946997 creator A5078662983 @default.
- W3080946997 creator A5089637336 @default.
- W3080946997 date "2020-01-01" @default.
- W3080946997 modified "2023-09-23" @default.
- W3080946997 title "Identifying gene signatures for cancer drug repositioning based on sample clustering" @default.
- W3080946997 doi "https://doi.org/10.1109/tcbb.2020.3019781" @default.
- W3080946997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32845842" @default.
- W3080946997 hasPublicationYear "2020" @default.
- W3080946997 type Work @default.
- W3080946997 sameAs 3080946997 @default.
- W3080946997 citedByCount "4" @default.
- W3080946997 countsByYear W30809469972021 @default.
- W3080946997 countsByYear W30809469972022 @default.
- W3080946997 countsByYear W30809469972023 @default.
- W3080946997 crossrefType "journal-article" @default.
- W3080946997 hasAuthorship W3080946997A5023697352 @default.
- W3080946997 hasAuthorship W3080946997A5031510017 @default.
- W3080946997 hasAuthorship W3080946997A5058768577 @default.
- W3080946997 hasAuthorship W3080946997A5078662983 @default.
- W3080946997 hasAuthorship W3080946997A5089637336 @default.
- W3080946997 hasConcept C103637391 @default.
- W3080946997 hasConcept C104317684 @default.
- W3080946997 hasConcept C124101348 @default.
- W3080946997 hasConcept C126838900 @default.
- W3080946997 hasConcept C150194340 @default.
- W3080946997 hasConcept C154945302 @default.
- W3080946997 hasConcept C183115368 @default.
- W3080946997 hasConcept C2524010 @default.
- W3080946997 hasConcept C2779696439 @default.
- W3080946997 hasConcept C2779733811 @default.
- W3080946997 hasConcept C2780035454 @default.
- W3080946997 hasConcept C33923547 @default.
- W3080946997 hasConcept C41008148 @default.
- W3080946997 hasConcept C54355233 @default.
- W3080946997 hasConcept C60644358 @default.
- W3080946997 hasConcept C70721500 @default.
- W3080946997 hasConcept C71924100 @default.
- W3080946997 hasConcept C73555534 @default.
- W3080946997 hasConcept C86803240 @default.
- W3080946997 hasConcept C98274493 @default.
- W3080946997 hasConceptScore W3080946997C103637391 @default.
- W3080946997 hasConceptScore W3080946997C104317684 @default.
- W3080946997 hasConceptScore W3080946997C124101348 @default.
- W3080946997 hasConceptScore W3080946997C126838900 @default.
- W3080946997 hasConceptScore W3080946997C150194340 @default.
- W3080946997 hasConceptScore W3080946997C154945302 @default.
- W3080946997 hasConceptScore W3080946997C183115368 @default.
- W3080946997 hasConceptScore W3080946997C2524010 @default.
- W3080946997 hasConceptScore W3080946997C2779696439 @default.
- W3080946997 hasConceptScore W3080946997C2779733811 @default.
- W3080946997 hasConceptScore W3080946997C2780035454 @default.
- W3080946997 hasConceptScore W3080946997C33923547 @default.
- W3080946997 hasConceptScore W3080946997C41008148 @default.
- W3080946997 hasConceptScore W3080946997C54355233 @default.
- W3080946997 hasConceptScore W3080946997C60644358 @default.
- W3080946997 hasConceptScore W3080946997C70721500 @default.
- W3080946997 hasConceptScore W3080946997C71924100 @default.
- W3080946997 hasConceptScore W3080946997C73555534 @default.
- W3080946997 hasConceptScore W3080946997C86803240 @default.
- W3080946997 hasConceptScore W3080946997C98274493 @default.
- W3080946997 hasFunder F4320321001 @default.
- W3080946997 hasFunder F4320322725 @default.
- W3080946997 hasFunder F4320334593 @default.
- W3080946997 hasLocation W30809469971 @default.
- W3080946997 hasLocation W30809469972 @default.
- W3080946997 hasOpenAccess W3080946997 @default.
- W3080946997 hasPrimaryLocation W30809469971 @default.
- W3080946997 hasRelatedWork W1588204645 @default.
- W3080946997 hasRelatedWork W2037927825 @default.
- W3080946997 hasRelatedWork W2063738382 @default.
- W3080946997 hasRelatedWork W2125986988 @default.
- W3080946997 hasRelatedWork W2148679377 @default.
- W3080946997 hasRelatedWork W2283281090 @default.
- W3080946997 hasRelatedWork W2874540278 @default.
- W3080946997 hasRelatedWork W3005667058 @default.
- W3080946997 hasRelatedWork W3133027190 @default.
- W3080946997 hasRelatedWork W3164749183 @default.
- W3080946997 isParatext "false" @default.
- W3080946997 isRetracted "false" @default.
- W3080946997 magId "3080946997" @default.
- W3080946997 workType "article" @default.