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- W3080949148 abstract "The disease tularemia is caused by the highly infectious Gram-negative pathogen Francisella tularensis . This bacterium encodes few regulatory factors (e.g., two-component systems [TCS]). PmrA, required for intramacrophage survival and virulence in the mouse model, is encoded by an orphan TCS response regulator gene. It is unclear how PmrA is responsive to environmental signals to regulate loci, including the PmrA-repressed gene priM . We identify an orphan sensor kinase (QseC) that is required for priM repression and further explore both environmental signals that might regulate the QseC-PmrA TCS and the function of PriM." @default.
- W3080949148 created "2020-09-01" @default.
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- W3080949148 date "2020-10-08" @default.
- W3080949148 modified "2023-09-27" @default.
- W3080949148 title "The Sensor Kinase QseC Regulates the Unlinked PmrA Response Regulator and Downstream Gene Expression in Francisella" @default.
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- W3080949148 doi "https://doi.org/10.1128/jb.00321-20" @default.
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