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• W3080956406 endingPage "138" @default.
• W3080956406 startingPage "128" @default.
• W3080956406 abstract "Inflammatory bowel disease (IBD) is a chronic and progressive disorder with destructive inflammation in the gastrointestinal tract (GIT). Biologics have changed the management of IBD, but have serious limitations, which is associated with their systemic administration via injection. Oral administration is the most accepted route of drug administration. However, the physiological barriers of the GIT pose significant challenges for oral administration of biologics, making this route of administration currently unavailable. The status of tissue barriers to oral drug delivery is altered in IBD. This may bring more challenges, but also present opportunities for oral delivery of biologics. This article provides an overview of disease-induced alterations of GIT barriers in IBD and discusses challenges, opportunities and commonly-utilised strategies for oral delivery of complex therapeutics, including biologics and nanomedicines." @default.
• W3080956406 created "2020-09-01" @default.
• W3080956406 creator A5007460215 @default.
• W3080956406 creator A5028239387 @default.
• W3080956406 creator A5045333123 @default.
• W3080956406 date "2020-10-01" @default.
• W3080956406 modified "2023-09-23" @default.
• W3080956406 title "Exploiting disease-induced changes for targeted oral delivery of biologics and nanomedicines in inflammatory bowel disease" @default.
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