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• W3080964749 abstract "The controversy of adjuvant radiotherapy of meningiomas is at least partially due to the insufficient understanding on meningioma cells’ response to irradiation and the shortage of radiosensitivity-promotion methods. MicroRNA-221 and microRNA-222 were identified as critical regulators of radiosensitivity in several other tumors. However, their effect in meningiomas has yet to be confirmed. Therefore, the malignant meningioma IOMM-Lee cells were adopted, transfected with microRNA-221/222 mimics or inhibitors and irradiated with different dosages. The effects of radiation and microRNA-221/222 were then assessed in vitro and in vivo. Radiation dose increases and microRNA-221/222 downregulation synergistically inhibited cell proliferation and colony formation, prevented xenograft tumor progression and promoted apoptosis, but antagonistically regulated cell invasiveness. Pairwise comparisons revealed that only high-dose radiations (6 Gy and 8 Gy) can significantly promote cell invasiveness in comparison with unirradiated counterparts. Further comparisons exhibited that downregulating the microRNA-221/222 expression can reverse this radiation-induced cell invasiveness to a level of untransfected and unirradiated cells only if cells were irradiated with no more than 6 Gy. In addition, this approach can promote IOMM-Lee’s radiosensitivity. Meanwhile, we also detected that the dose rate of irradiation affects cell cycle distribution and cell apoptosis of IOMM-Lee. A high dose rate irradiation induces G0/G1 cell cycle arrest and apoptosis-promoting effect. Therefore, for malignant meningiomas, high-dose irradiation can facilitate cell invasiveness significantly. Downregulating the microRNA-221/222 level can reverse the radiation-induced cell invasiveness while enhancing the apoptosis-promoting and proliferation-inhibiting effects of radiation and promoting cell radiosensitivity." @default.
• W3080964749 created "2020-09-01" @default.
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• W3080964749 date "2020-08-25" @default.
• W3080964749 modified "2023-10-10" @default.
• W3080964749 title "MicroRNA-221/222 Inhibits the Radiation-Induced Invasiveness and Promotes the Radiosensitivity of Malignant Meningioma Cells" @default.
• W3080964749 cites W144423133 @default.
• W3080964749 cites W1591472489 @default.
• W3080964749 cites W1606289298 @default.
• W3080964749 cites W1780348968 @default.
• W3080964749 cites W1887368958 @default.
• W3080964749 cites W1893588436 @default.
• W3080964749 cites W1902166027 @default.
• W3080964749 cites W1914368755 @default.
• W3080964749 cites W1969183124 @default.
• W3080964749 cites W1976899677 @default.
• W3080964749 cites W1981027541 @default.
• W3080964749 cites W1981149350 @default.
• W3080964749 cites W1987004461 @default.
• W3080964749 cites W1989831932 @default.
• W3080964749 cites W1990365150 @default.
• W3080964749 cites W1991494214 @default.
• W3080964749 cites W2002082209 @default.
• W3080964749 cites W2004445019 @default.
• W3080964749 cites W2012410089 @default.
• W3080964749 cites W2013224015 @default.
• W3080964749 cites W2016757970 @default.
• W3080964749 cites W2021726330 @default.
• W3080964749 cites W2023557031 @default.
• W3080964749 cites W2025647419 @default.
• W3080964749 cites W2040881358 @default.
• W3080964749 cites W2041221777 @default.
• W3080964749 cites W2049633890 @default.
• W3080964749 cites W2051215110 @default.
• W3080964749 cites W2051385844 @default.
• W3080964749 cites W2060459012 @default.
• W3080964749 cites W2076531398 @default.
• W3080964749 cites W2077867969 @default.
• W3080964749 cites W2081201480 @default.
• W3080964749 cites W2082873059 @default.
• W3080964749 cites W2083604274 @default.
• W3080964749 cites W2090408878 @default.
• W3080964749 cites W2091273754 @default.
• W3080964749 cites W2094001485 @default.
• W3080964749 cites W2097267553 @default.
• W3080964749 cites W2100971443 @default.
• W3080964749 cites W2101547995 @default.
• W3080964749 cites W2102681919 @default.
• W3080964749 cites W2104546896 @default.
• W3080964749 cites W2117139716 @default.
• W3080964749 cites W2120921507 @default.
• W3080964749 cites W2122656686 @default.
• W3080964749 cites W2122966362 @default.
• W3080964749 cites W2124269758 @default.
• W3080964749 cites W2126309017 @default.
• W3080964749 cites W2131833681 @default.
• W3080964749 cites W2135517721 @default.
• W3080964749 cites W2135838271 @default.
• W3080964749 cites W2137267184 @default.
• W3080964749 cites W2144323242 @default.
• W3080964749 cites W2149060599 @default.
• W3080964749 cites W2149955441 @default.
• W3080964749 cites W2150710841 @default.
• W3080964749 cites W2153953411 @default.
• W3080964749 cites W2153977140 @default.
• W3080964749 cites W2156480607 @default.
• W3080964749 cites W2160382843 @default.
• W3080964749 cites W2160919000 @default.
• W3080964749 cites W2225929636 @default.
• W3080964749 cites W2291320440 @default.
• W3080964749 cites W2318158463 @default.
• W3080964749 cites W2401586560 @default.
• W3080964749 cites W2477730346 @default.
• W3080964749 cites W2513583075 @default.
• W3080964749 cites W2538136738 @default.
• W3080964749 cites W2573963236 @default.
• W3080964749 cites W2603111952 @default.
• W3080964749 cites W2603230398 @default.
• W3080964749 cites W2746406826 @default.
• W3080964749 cites W2753901940 @default.
• W3080964749 cites W2766638837 @default.
• W3080964749 cites W2772173460 @default.
• W3080964749 cites W2773893290 @default.
• W3080964749 cites W2811459570 @default.
• W3080964749 cites W2866328586 @default.
• W3080964749 cites W2902977134 @default.
• W3080964749 cites W2915439538 @default.
• W3080964749 doi "https://doi.org/10.3389/fonc.2020.01441" @default.

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