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- W3080972408 abstract "ABSTRACT Production of secondary metabolites is tightly regulated by transcriptional regulators in Streptomyces. Many regulators have been identified by gene disruption in Streptomyces; however, there are still unknown regulatory genes yet to be revealed due to gene silence under laboratory culture conditions. In present study, a T7 expression system was used to identify novel regulators by gene deletion and constitutive-expression of nine candidates. We reported that the constitutive-expression of a MarR family transcriptional regulator MapR (SCO2398) resulted in increase of actinorhodin (ACT) production. The expression profiling indicated that MapR regulates ACT production through a transcriptional cascade. Collectively, our study suggests that MapR serves as a novel positive regulator of ACT production." @default.
- W3080972408 created "2020-09-01" @default.
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- W3080972408 date "2020-08-21" @default.
- W3080972408 modified "2023-09-25" @default.
- W3080972408 title "A MarR-family transcriptional factor MapR positively regulates actinorhodin production in <i>Streptomyces coelicolor</i>" @default.
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- W3080972408 doi "https://doi.org/10.1093/femsle/fnaa140" @default.
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