FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080994108> ?p ?o ?g. }

• W3080994108 endingPage "11413" @default.
• W3080994108 startingPage "11405" @default.
• W3080994108 abstract "Fine particulate matter (PM2.5) and ozone (O3) may exert oxidative damage in the nose, which is hypothesized to be associated with worsened asthma symptoms. This study, hence, is to explore whether an oxidative stress biomarker, malondialdehyde (MDA) in the nasal fluid, has the potential to aid personalized asthma control. In a panel study of 43 asthmatic children, 5–13 years old, each child was measured 4 times with a 2-week interval between consecutive clinic visits. At each visit, nasal fluid and urine samples were collected, and fractional exhaled nitric oxide (FeNO) was measured as a biomarker of pulmonary inflammation. In addition to nasal MDA, urinary MDA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were measured as biomarkers of systemic oxidative stress. We also assessed asthma symptoms using the Childhood Asthma-Control Test (C-ACT). We found that interquartile range (IQR) increases in 24 h average personal PM2.5 exposure (22.2–33.5 μg/m3), estimated 0 to 5 days prior to a clinic visit, were associated with increased nasal MDA concentrations by 38.6–54.9%. Similarly, IQR increases in 24 h average personal O3 exposure (7.7–8.2 ppb) estimated 2 to 4 days prior were associated with increased nasal MDA by 22.1–69.4%. Only increased PM2.5 exposure was associated with increased FeNO. Increased nasal MDA concentration was associated with decreased total and individual C-ACT scores, indicating worsening of asthma symptoms. However, no significant associations were observed between urinary MDA or 8-OHdG and C-ACT scores. The results confirm that oxidative stress plays an important role in linking air pollution exposure and adverse respiratory health effects. These findings support that MDA in the nasal fluid may serve as a useful biomarker for monitoring asthma status, especially in relation to PM2.5 and O3 exposures, two known risk factors of asthma exacerbation." @default.
• W3080994108 created "2020-09-01" @default.
• W3080994108 creator A5001636682 @default.
• W3080994108 creator A5006123972 @default.
• W3080994108 creator A5010444377 @default.
• W3080994108 creator A5015224628 @default.
• W3080994108 creator A5017135366 @default.
• W3080994108 creator A5020896191 @default.
• W3080994108 creator A5021198434 @default.
• W3080994108 creator A5025172140 @default.
• W3080994108 creator A5028199089 @default.
• W3080994108 creator A5034969848 @default.
• W3080994108 creator A5036788286 @default.
• W3080994108 creator A5046225712 @default.
• W3080994108 creator A5055897234 @default.
• W3080994108 creator A5063776121 @default.
• W3080994108 creator A5072187489 @default.
• W3080994108 creator A5078340797 @default.
• W3080994108 creator A5081844561 @default.
• W3080994108 date "2020-08-21" @default.
• W3080994108 modified "2023-10-17" @default.
• W3080994108 title "Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure" @default.
• W3080994108 cites W185214452 @default.
• W3080994108 cites W1978973968 @default.
• W3080994108 cites W1981015531 @default.
• W3080994108 cites W1982901502 @default.
• W3080994108 cites W1989935661 @default.
• W3080994108 cites W1991428500 @default.
• W3080994108 cites W2007104943 @default.
• W3080994108 cites W2020383780 @default.
• W3080994108 cites W2022758463 @default.
• W3080994108 cites W2066939127 @default.
• W3080994108 cites W2078372877 @default.
• W3080994108 cites W2083753594 @default.
• W3080994108 cites W2089479653 @default.
• W3080994108 cites W2099537288 @default.
• W3080994108 cites W2107838068 @default.
• W3080994108 cites W2109373190 @default.
• W3080994108 cites W2126939562 @default.
• W3080994108 cites W2136779632 @default.
• W3080994108 cites W2141343329 @default.
• W3080994108 cites W2141970008 @default.
• W3080994108 cites W2160624031 @default.
• W3080994108 cites W2171571902 @default.
• W3080994108 cites W2398399679 @default.
• W3080994108 cites W2533405373 @default.
• W3080994108 cites W2567034171 @default.
• W3080994108 cites W2582797467 @default.
• W3080994108 cites W2791403224 @default.
• W3080994108 cites W2791740451 @default.
• W3080994108 cites W2795407629 @default.
• W3080994108 cites W2801553349 @default.
• W3080994108 cites W2803335400 @default.
• W3080994108 cites W2884408658 @default.
• W3080994108 cites W2917992354 @default.
• W3080994108 cites W2941866204 @default.
• W3080994108 cites W2944351160 @default.
• W3080994108 cites W2952073230 @default.
• W3080994108 cites W2962301192 @default.
• W3080994108 cites W2978213536 @default.
• W3080994108 cites W2982362299 @default.
• W3080994108 cites W2982749968 @default.
• W3080994108 cites W2983355835 @default.
• W3080994108 cites W2996298508 @default.
• W3080994108 cites W3011118089 @default.
• W3080994108 cites W3014791786 @default.
• W3080994108 cites W3014891282 @default.
• W3080994108 cites W3041547647 @default.
• W3080994108 cites W3046884452 @default.
• W3080994108 doi "https://doi.org/10.1021/acs.est.0c02558" @default.
• W3080994108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32822160" @default.
• W3080994108 hasPublicationYear "2020" @default.
• W3080994108 type Work @default.
• W3080994108 sameAs 3080994108 @default.
• W3080994108 citedByCount "18" @default.
• W3080994108 countsByYear W30809941082020 @default.
• W3080994108 countsByYear W30809941082021 @default.
• W3080994108 countsByYear W30809941082022 @default.
• W3080994108 countsByYear W30809941082023 @default.
• W3080994108 crossrefType "journal-article" @default.
• W3080994108 hasAuthorship W3080994108A5001636682 @default.
• W3080994108 hasAuthorship W3080994108A5006123972 @default.
• W3080994108 hasAuthorship W3080994108A5010444377 @default.
• W3080994108 hasAuthorship W3080994108A5015224628 @default.
• W3080994108 hasAuthorship W3080994108A5017135366 @default.
• W3080994108 hasAuthorship W3080994108A5020896191 @default.
• W3080994108 hasAuthorship W3080994108A5021198434 @default.
• W3080994108 hasAuthorship W3080994108A5025172140 @default.
• W3080994108 hasAuthorship W3080994108A5028199089 @default.
• W3080994108 hasAuthorship W3080994108A5034969848 @default.
• W3080994108 hasAuthorship W3080994108A5036788286 @default.
• W3080994108 hasAuthorship W3080994108A5046225712 @default.
• W3080994108 hasAuthorship W3080994108A5055897234 @default.
• W3080994108 hasAuthorship W3080994108A5063776121 @default.
• W3080994108 hasAuthorship W3080994108A5072187489 @default.
• W3080994108 hasAuthorship W3080994108A5078340797 @default.
• W3080994108 hasAuthorship W3080994108A5081844561 @default.
• W3080994108 hasConcept C119060515 @default.

• next