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- W3081020009 abstract "Candida auris is among the most important emerging fungal pathogens, yet mechanistic insights into its immune recognition and control are lacking. Here, we integrate transcriptional and functional immune-cell profiling to uncover innate defence mechanisms against C. auris. C. auris induces a specific transcriptome in human mononuclear cells, a stronger cytokine response compared with Candida albicans, but a lower macrophage lysis capacity. C. auris-induced innate immune activation is mediated through the recognition of C-type lectin receptors, mainly elicited by structurally unique C. auris mannoproteins. In in vivo experimental models of disseminated candidiasis, C. auris was less virulent than C. albicans. Collectively, these results demonstrate that C. auris is a strong inducer of innate host defence, and identify possible targets for adjuvant immunotherapy. Transcriptional and functional immune-cell profiling reveals that Candida auris is a strong inducer of innate host defence and identifies possible targets for adjuvant immunotherapy." @default.
- W3081020009 created "2020-09-01" @default.
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- W3081020009 date "2020-08-24" @default.
- W3081020009 modified "2023-10-15" @default.
- W3081020009 title "Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris" @default.
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- W3081020009 doi "https://doi.org/10.1038/s41564-020-0780-3" @default.
- W3081020009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32839538" @default.
- W3081020009 hasPublicationYear "2020" @default.
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