Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081025308> ?p ?o ?g. }
- W3081025308 abstract "Abstract Breast cancer survivors treated with anti-estrogen therapies report weight gain and have an elevated risk of type 2 diabetes. Here, we show that current tamoxifen use associated with larger breast adipocyte diameter only in women with a BMI >30 kg/m 2 . To understand the mechanisms behind these clinical findings, we investigated the impact of estrogen deprivation and tamoxifen in a relevant pre-clinical model of obesity. Specifically, mature female mice were housed at thermoneutrality and fed either a low-fat/low-sucrose (LFLS) or a high-fat/high-sucrose (HFHS) diet. Consistent with the high expression of Esr1 observed in single-cell RNA sequencing of mesenchymal stem cells from adipose tissue, endocrine therapies induced adipose accumulation and preadipocyte expansion, but resulted in adipocyte progenitor depletion only in the context of HFHS. Consequently, 7-week endocrine therapy supported adipocyte hypertrophy and was associated with hepatic steatosis, hyperinsulinemia, insulin resistance, and glucose intolerance, particularly in HFHS fed females. Metformin or pioglitazone, glucose lowering drugs used to treat diabetes, prevented the effects of tamoxifen but not estrogen deprivation on adipocyte size and insulin resistance in HFHS-fed mice. This translational study suggests that endocrine therapies act via ERα to directly disrupt adipocyte progenitors and support adipocyte hypertrophy, leading to ectopic lipid deposition that may promote hyperinsulinemia, insulin resistance and type 2 diabetes. Interventions that target insulin action should be considered for some women receiving life-saving endocrine therapies for breast cancer." @default.
- W3081025308 created "2020-09-01" @default.
- W3081025308 creator A5001346711 @default.
- W3081025308 creator A5002596876 @default.
- W3081025308 creator A5007617029 @default.
- W3081025308 creator A5029406825 @default.
- W3081025308 creator A5033772545 @default.
- W3081025308 creator A5043317034 @default.
- W3081025308 creator A5047281126 @default.
- W3081025308 creator A5054152834 @default.
- W3081025308 creator A5055826409 @default.
- W3081025308 creator A5058090404 @default.
- W3081025308 creator A5068543970 @default.
- W3081025308 creator A5068581300 @default.
- W3081025308 creator A5074813217 @default.
- W3081025308 creator A5078763142 @default.
- W3081025308 creator A5085569297 @default.
- W3081025308 creator A5085989501 @default.
- W3081025308 creator A5088228514 @default.
- W3081025308 date "2020-08-23" @default.
- W3081025308 modified "2023-09-27" @default.
- W3081025308 title "Breast cancer endocrine therapy exhausts adipocyte progenitors promoting weight gain and glucose intolerance" @default.
- W3081025308 cites W1480532714 @default.
- W3081025308 cites W1900255806 @default.
- W3081025308 cites W191921287 @default.
- W3081025308 cites W1963384348 @default.
- W3081025308 cites W1977715345 @default.
- W3081025308 cites W1978988408 @default.
- W3081025308 cites W1979571494 @default.
- W3081025308 cites W1979733406 @default.
- W3081025308 cites W1980484723 @default.
- W3081025308 cites W1982619627 @default.
- W3081025308 cites W1992453950 @default.
- W3081025308 cites W1999756228 @default.
- W3081025308 cites W2000524154 @default.
- W3081025308 cites W2015859860 @default.
- W3081025308 cites W2023271280 @default.
- W3081025308 cites W2035676023 @default.
- W3081025308 cites W2037061925 @default.
- W3081025308 cites W2043123806 @default.
- W3081025308 cites W2044021940 @default.
- W3081025308 cites W2047683706 @default.
- W3081025308 cites W2052073560 @default.
- W3081025308 cites W2063236170 @default.
- W3081025308 cites W2075483533 @default.
- W3081025308 cites W2078634603 @default.
- W3081025308 cites W2081946059 @default.
- W3081025308 cites W2084797042 @default.
- W3081025308 cites W2096686828 @default.
- W3081025308 cites W2103156933 @default.
- W3081025308 cites W2104062909 @default.
- W3081025308 cites W2106618732 @default.
- W3081025308 cites W2115375080 @default.
- W3081025308 cites W2123383121 @default.
- W3081025308 cites W2124138867 @default.
- W3081025308 cites W2131199058 @default.
- W3081025308 cites W2145533373 @default.
- W3081025308 cites W2150767656 @default.
- W3081025308 cites W2155658630 @default.
- W3081025308 cites W2158630041 @default.
- W3081025308 cites W2159427817 @default.
- W3081025308 cites W2159583302 @default.
- W3081025308 cites W2160078193 @default.
- W3081025308 cites W2161977537 @default.
- W3081025308 cites W2162478301 @default.
- W3081025308 cites W2166822410 @default.
- W3081025308 cites W2166874780 @default.
- W3081025308 cites W2171457431 @default.
- W3081025308 cites W2313551916 @default.
- W3081025308 cites W2316193238 @default.
- W3081025308 cites W2428513306 @default.
- W3081025308 cites W2463503062 @default.
- W3081025308 cites W2578294307 @default.
- W3081025308 cites W2585504477 @default.
- W3081025308 cites W2737050892 @default.
- W3081025308 cites W2750109605 @default.
- W3081025308 cites W2790952412 @default.
- W3081025308 cites W2797783284 @default.
- W3081025308 cites W2802952010 @default.
- W3081025308 cites W2804386169 @default.
- W3081025308 cites W2805456840 @default.
- W3081025308 cites W2806334900 @default.
- W3081025308 cites W2808137256 @default.
- W3081025308 cites W2883652949 @default.
- W3081025308 cites W2885541768 @default.
- W3081025308 cites W2889771614 @default.
- W3081025308 cites W2891073245 @default.
- W3081025308 cites W2894687190 @default.
- W3081025308 cites W2910068212 @default.
- W3081025308 cites W2911912792 @default.
- W3081025308 cites W2912818583 @default.
- W3081025308 cites W2913465969 @default.
- W3081025308 cites W2930021946 @default.
- W3081025308 cites W2942273685 @default.
- W3081025308 cites W2943159849 @default.
- W3081025308 cites W2971583637 @default.
- W3081025308 cites W2972283693 @default.
- W3081025308 cites W2982007450 @default.
- W3081025308 cites W3047361803 @default.
- W3081025308 cites W4247709980 @default.