Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081041302> ?p ?o ?g. }
- W3081041302 abstract "Angiotensin-converting enzyme 2 (ACE2), a specific high-affinity angiotensin II-hydrolytic enzyme, is the vector that facilitates cellular entry of SARS-CoV-1 and the novel SARS-CoV-2 coronavirus. SARS-CoV-2, which crossed species barriers to infect humans, is highly contagious and associated with high lethality due to multi-organ failure, mostly in older patients with other co-morbidities.Accumulating clinical evidence demonstrates that the intensity of the infection and its complications are more prominent in men. It has been postulated that potential functional modulation of ACE2 by estrogen may explain the sex difference in morbidity and mortality. We review here the evidence regarding the role of estrogenic hormones in ACE2 expression and regulation, with the intent of bringing to the forefront potential mechanisms that may explain sex differences in SARS-CoV-2 infection and COVID-19 outcomes, assist in management of COVID-19, and uncover new therapeutic strategies." @default.
- W3081041302 created "2020-09-01" @default.
- W3081041302 creator A5014633095 @default.
- W3081041302 creator A5070404220 @default.
- W3081041302 creator A5083220247 @default.
- W3081041302 creator A5086613360 @default.
- W3081041302 creator A5088391372 @default.
- W3081041302 date "2020-08-27" @default.
- W3081041302 modified "2023-10-14" @default.
- W3081041302 title "Is Sex a Determinant of COVID-19 Infection? Truth or Myth?" @default.
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