FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081059830> ?p ?o ?g. }

• W3081059830 endingPage "2185" @default.
• W3081059830 startingPage "2175" @default.
• W3081059830 abstract "Abstract Cancer stem cells (CSC) are highly resistant to conventional chemotherapeutic drugs. YAP1 and STAT3 are the two transcription factors that facilitate the therapeutic resistance and expansion of CSCs. The objective of this study was to understand the cross-talk between YAP1 and STAT3 activities and to determine the therapeutic efficacy of targeting dual CSC-regulating pathways (YAP1 and STAT3) combined with chemotherapy in lung adenocarcinoma. Here, we showed that YAP1 contributes to CSC regulation and enhances tumor formation while suppressing apoptosis. Mechanistically, YAP1 promotes phosphorylation of STAT3 by upregulating IL6. In lung adenocarcinoma clinical specimens, YAP1 expression correlated with that of IL6 (P &lt; 0.01). More importantly, YAP1 and phosphorylated STAT3 (pSTAT3) protein expressions were significantly correlated (P &lt; 0.0001) in primary lung adenocarcinoma as determined by IHC. Immunoblotting of 13 lung adenocarcinoma patient-derived xenografts (PDX) showed that all YAP1-expressing PDXs also exhibited pSTAT3. Additional investigations revealed that chemotherapy resistance and malignant stemness were influenced by upregulating NANOG, OCT4, and SOX2, and the expression of these targets significantly attenuated by genetically and pharmacologically hindering the activities of YAP1 and STAT3 in vivo and in vitro. Therapeutically, the dual inhibition of YAP1 and STAT3 elicits a long-lasting therapeutic response by limiting CSC expansion following chemotherapy in cell line xenograft and PDX models of lung adenocarcinoma. Collectively, these findings provide a conceptual framework to target the YAP1 and STAT3 pathways concurrently with systemic chemotherapy to improve the clinical management of lung adenocarcinoma, based on evidence that these two pathways expand CSC populations that mediate resistance to chemotherapy." @default.
• W3081059830 created "2020-09-01" @default.
• W3081059830 creator A5003842701 @default.
• W3081059830 creator A5007396993 @default.
• W3081059830 creator A5012297126 @default.
• W3081059830 creator A5014646068 @default.
• W3081059830 creator A5018732755 @default.
• W3081059830 creator A5025811477 @default.
• W3081059830 creator A5027033402 @default.
• W3081059830 creator A5040892054 @default.
• W3081059830 creator A5049524331 @default.
• W3081059830 creator A5050703359 @default.
• W3081059830 creator A5075981680 @default.
• W3081059830 creator A5089742010 @default.
• W3081059830 date "2020-10-01" @default.
• W3081059830 modified "2023-10-15" @default.
• W3081059830 title "Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy" @default.
• W3081059830 cites W1812164980 @default.
• W3081059830 cites W1946834020 @default.
• W3081059830 cites W2007840001 @default.
• W3081059830 cites W2018252938 @default.
• W3081059830 cites W2043217368 @default.
• W3081059830 cites W2099805317 @default.
• W3081059830 cites W2100641053 @default.
• W3081059830 cites W2101197781 @default.
• W3081059830 cites W2134751585 @default.
• W3081059830 cites W2144330604 @default.
• W3081059830 cites W2148168351 @default.
• W3081059830 cites W2158076916 @default.
• W3081059830 cites W2170476872 @default.
• W3081059830 cites W2217303697 @default.
• W3081059830 cites W2226127569 @default.
• W3081059830 cites W2266087322 @default.
• W3081059830 cites W2341467683 @default.
• W3081059830 cites W2341829316 @default.
• W3081059830 cites W2406860897 @default.
• W3081059830 cites W2481496926 @default.
• W3081059830 cites W2487941004 @default.
• W3081059830 cites W2525090472 @default.
• W3081059830 cites W2582402649 @default.
• W3081059830 cites W2590474354 @default.
• W3081059830 cites W2590908436 @default.
• W3081059830 cites W2600392992 @default.
• W3081059830 cites W2603774629 @default.
• W3081059830 cites W2605409215 @default.
• W3081059830 cites W2702276313 @default.
• W3081059830 cites W2710038794 @default.
• W3081059830 cites W2727474048 @default.
• W3081059830 cites W2735458523 @default.
• W3081059830 cites W2736694159 @default.
• W3081059830 cites W2741226048 @default.
• W3081059830 cites W2743896081 @default.
• W3081059830 cites W2750926847 @default.
• W3081059830 cites W2770733474 @default.
• W3081059830 cites W2783729838 @default.
• W3081059830 cites W2786987313 @default.
• W3081059830 cites W2789122080 @default.
• W3081059830 cites W2789478657 @default.
• W3081059830 cites W2796576424 @default.
• W3081059830 cites W2800631768 @default.
• W3081059830 cites W2802787991 @default.
• W3081059830 cites W2802901867 @default.
• W3081059830 cites W2890838997 @default.
• W3081059830 cites W2896950141 @default.
• W3081059830 cites W2946473529 @default.
• W3081059830 cites W2981063657 @default.
• W3081059830 cites W3000285141 @default.
• W3081059830 doi "https://doi.org/10.1158/1535-7163.mct-20-0024" @default.
• W3081059830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7541748" @default.
• W3081059830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32847981" @default.
• W3081059830 hasPublicationYear "2020" @default.
• W3081059830 type Work @default.
• W3081059830 sameAs 3081059830 @default.
• W3081059830 citedByCount "7" @default.
• W3081059830 countsByYear W30810598302020 @default.
• W3081059830 countsByYear W30810598302021 @default.
• W3081059830 countsByYear W30810598302022 @default.
• W3081059830 countsByYear W30810598302023 @default.
• W3081059830 crossrefType "journal-article" @default.
• W3081059830 hasAuthorship W3081059830A5003842701 @default.
• W3081059830 hasAuthorship W3081059830A5007396993 @default.
• W3081059830 hasAuthorship W3081059830A5012297126 @default.
• W3081059830 hasAuthorship W3081059830A5014646068 @default.
• W3081059830 hasAuthorship W3081059830A5018732755 @default.
• W3081059830 hasAuthorship W3081059830A5025811477 @default.
• W3081059830 hasAuthorship W3081059830A5027033402 @default.
• W3081059830 hasAuthorship W3081059830A5040892054 @default.
• W3081059830 hasAuthorship W3081059830A5049524331 @default.
• W3081059830 hasAuthorship W3081059830A5050703359 @default.
• W3081059830 hasAuthorship W3081059830A5075981680 @default.
• W3081059830 hasAuthorship W3081059830A5089742010 @default.
• W3081059830 hasBestOaLocation W30810598301 @default.
• W3081059830 hasConcept C104317684 @default.
• W3081059830 hasConcept C121608353 @default.
• W3081059830 hasConcept C126322002 @default.
• W3081059830 hasConcept C143998085 @default.
• W3081059830 hasConcept C2776256026 @default.
• W3081059830 hasConcept C2777933648 @default.

• next