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- W3081065812 abstract "Homologous recombination is a critical mechanism for the repair of DNA double-strand breaks (DSBs). It occurs predominantly between identical sister chromatids and at lower frequency can also occur between homologs. Interhomolog homologous recombination (IH-HR) has the potential lead to substantial loss of genetic information, i.e., loss of heterozygosity (LOH), when it is accompanied by crossing over. In this chapter, we describe a system to study IH-HR induced by a defined DSB in mouse embryonic stem cells derived from F1 hybrid mice. This system is based on the placement of mutant selectable marker genes, one of which contains an I-SceI endonuclease cleavage site, on the two homologs such that repair of the I-SceI-generated DSB from the homolog leads to drug resistance. Loss of heterozygosity arising during IH-HR is analyzed using a PCR-based approach. Finally, we present a strategy to analyze the role of BLM helicase in this system." @default.
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- W3081065812 date "2020-08-26" @default.
- W3081065812 modified "2023-10-01" @default.
- W3081065812 title "Interhomolog Homologous Recombination in Mouse Embryonic Stem Cells" @default.
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- W3081065812 doi "https://doi.org/10.1007/978-1-0716-0644-5_10" @default.
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