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- W3081101050 abstract "DNA- and protein-binding properties, cellular uptake, and cytotoxicity activity of a mononuclear copper(II) complex, [CuLCl2] (1, where L = 4′-bis(pyridine-2-ylmethyl)amiono-2-phenylbenzothiazole), were investigated. The results show that 1 can effectively enter the cancer cells, even the nucleus, and exhibit cytotoxicity comparable to that of cisplatin against A549 and MCF-7 cell lines. Complex 1 could strongly bind to calf-thymus DNA (CT-DNA) mainly by intercalation mode and induce a remarkable conformational variation of DNA. The intrinsic binding constant Kb of 1 to DNA is 4.15 × 105 M−1 and the apparent binding constant Kapp is 1.25 × 106 M−1. Agarose gel electrophoresis revealed that 1 could efficiently cleave the supercoiled pBR322 DNA into its nicked and linear forms in the presence of excessive H2O2. The evaluation of the protein binding ability showed that 1 could also bind to human serum albumin (HSA) with a moderate binding affinity, quench the intrinsic fluorescence of HSA, and induce the conformational change of the protein." @default.
- W3081101050 created "2020-09-01" @default.
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- W3081101050 date "2020-07-17" @default.
- W3081101050 modified "2023-09-27" @default.
- W3081101050 title "Reactivity towards DNA and protein, cellular uptake, cytotoxic activity of a mononuclear copper(II) complex of the thioflavin-T (ThT)-based derivative" @default.
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- W3081101050 doi "https://doi.org/10.1080/00958972.2020.1808890" @default.
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