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• W3081111498 abstract "Spermatogenesis is a complex process that takes place under the influence of many different genes.The aim of this study was to investigate the possible effects of Ceratonia siliqua hydroalcoholic extract (CSHAE) on protamine gene expression, testicular function, and testicular histology in doxorubicin-treated rats.56 adult male rats with a age range of 2.5 to 3 months (210 ± 10 gr) were divided into seven groups (n = 8/each). A) Control group was left untreated; B) Sham group received 0.3 ml distilled water intraperitoneally, C) Negative control group received 3 mg/kg doxorubicin, intraperitoneally once a week for 28 days; and D) Positive control group received 600 mg/kg of CSHAE orally for 48 days; E, F, G) the experimental groups 1, 2, and 3 received 150, 300, and 600 mg/kg of CSHAE respectively orally, for 48 days, as well as 3 mg/kg doxorubicin once a week for 28 days. Hematoxylin-eosin staining was used in the histological study of testes, and enzyme-linked immunosorbent assay method was used in measuring serum levels of testosterone. Protamine gene expression was determined by real-Time PCR method.The mean body weight, testicular weight, testicular volume, testosterone level (p = 0.022), the count of Leydig, spermatogonia, spermatocyte, and spermatid cells, as well as protamine gene expression (p = 0.008) were significantly increased in the experimental group 2 compared to the negative control group. The regeneration of testicular tissue was observed in the experimental group 2.CSHAE has protective effect on doxorubicin-induced testicular injuries." @default.
• W3081111498 created "2020-09-01" @default.
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• W3081111498 date "2020-08-19" @default.
• W3081111498 modified "2023-09-25" @default.
• W3081111498 title "Protective effects of Ceratonia siliqua extract on protamine gene expression, testicular function, and testicular histology in doxorubicin-treated adult rats: An experimental study" @default.
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• W3081111498 doi "https://doi.org/10.18502/ijrm.v13i8.7507" @default.
• W3081111498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7457156" @default.
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• W3081111498 hasPublicationYear "2020" @default.
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