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• W3081113055 endingPage "112757" @default.
• W3081113055 startingPage "112757" @default.
• W3081113055 abstract "Development of new anti-bacterial agents acting upon underexploited targets and thus evading known mechanisms of resistance is the need of the hour. The highly conserved and distinct bacterial fatty acid biosynthesis pathway (FAS-II), presents a validated and yet relatively underexploited target for drug discovery. FabI and its isoforms (FabL, FabK, FabV and InhA) are essential enoyl-ACP reductases present in several microorganisms. In addition, the components of the FAS-II pathway are distinct from the multi-enzyme FAS-I complex found in mammals. Thus, inhibition of FabI and its isoforms is anticipated to result in broad-spectrum antibacterial activity. Several research groups from industry and academic laboratories have devoted significant efforts to develop effective FabI-targeting antibiotics, which are currently in various stages of clinical development for the treatment of multi-drug resistant bacterial infections. This review summarizes all the natural as well as synthetic inhibitors of gram-positive and gram-negative enoyl ACP reductases (FabI). The knowledge of the reported inhibitors can aid in the development of broad-spectrum antibacterials specifically targeting FabI enzymes from S. aureus , S. epidermidis , B. anthracis , B. cereus , E. coli, P. aeruginosa, P. falciparum and M. tuberculosis. • Bacterial FAS-II pathway presents a validated and yet relatively underexploited target for drug discovery. • Various synthetic and natural inhibitors of FabI and its isoforms are discussed. • Intervention in FAS-II pathway promises generation of antibiotics evading known mechanisms of resistance. • Inhibition of ENR/FabI leads to broad-spectrum antimicrobial activity." @default.
• W3081113055 created "2020-09-01" @default.
• W3081113055 creator A5026284616 @default.
• W3081113055 creator A5047918573 @default.
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• W3081113055 creator A5064048726 @default.
• W3081113055 creator A5076134247 @default.
• W3081113055 creator A5082576210 @default.
• W3081113055 date "2020-12-01" @default.
• W3081113055 modified "2023-09-23" @default.
• W3081113055 title "FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors" @default.
• W3081113055 cites W1152688639 @default.
• W3081113055 cites W1501884416 @default.
• W3081113055 cites W1656528362 @default.
• W3081113055 cites W1669810599 @default.
• W3081113055 cites W1955606533 @default.
• W3081113055 cites W1956996573 @default.
• W3081113055 cites W1968255354 @default.
• W3081113055 cites W1974790328 @default.
• W3081113055 cites W1976239530 @default.
• W3081113055 cites W1980595924 @default.
• W3081113055 cites W1982542062 @default.
• W3081113055 cites W1983181721 @default.
• W3081113055 cites W1989336473 @default.
• W3081113055 cites W1993562651 @default.
• W3081113055 cites W1996569068 @default.
• W3081113055 cites W2001885206 @default.
• W3081113055 cites W2003242056 @default.
• W3081113055 cites W2005201301 @default.
• W3081113055 cites W2006941404 @default.
• W3081113055 cites W2012248924 @default.
• W3081113055 cites W2012686105 @default.
• W3081113055 cites W2022361934 @default.
• W3081113055 cites W2023232635 @default.
• W3081113055 cites W2026487613 @default.
• W3081113055 cites W2030206626 @default.
• W3081113055 cites W2030256609 @default.
• W3081113055 cites W2038413365 @default.
• W3081113055 cites W2041529652 @default.
• W3081113055 cites W2044220325 @default.
• W3081113055 cites W2044632718 @default.
• W3081113055 cites W2045098462 @default.
• W3081113055 cites W2049872836 @default.
• W3081113055 cites W2053157153 @default.
• W3081113055 cites W2057546898 @default.
• W3081113055 cites W2058925610 @default.
• W3081113055 cites W2062192678 @default.
• W3081113055 cites W2062196932 @default.
• W3081113055 cites W2068064029 @default.
• W3081113055 cites W2069029926 @default.
• W3081113055 cites W2080841199 @default.
• W3081113055 cites W2093257821 @default.
• W3081113055 cites W2093440545 @default.
• W3081113055 cites W2094544263 @default.
• W3081113055 cites W2098544401 @default.
• W3081113055 cites W2098853663 @default.
• W3081113055 cites W2098941740 @default.
• W3081113055 cites W2103517471 @default.
• W3081113055 cites W2107109782 @default.
• W3081113055 cites W2109455981 @default.
• W3081113055 cites W2109654313 @default.
• W3081113055 cites W2109997476 @default.
• W3081113055 cites W2113461878 @default.
• W3081113055 cites W2115486016 @default.
• W3081113055 cites W2124135279 @default.
• W3081113055 cites W2125477183 @default.
• W3081113055 cites W2126265318 @default.
• W3081113055 cites W2127408950 @default.
• W3081113055 cites W2130209273 @default.
• W3081113055 cites W2131039226 @default.
• W3081113055 cites W2136608476 @default.
• W3081113055 cites W2137554060 @default.
• W3081113055 cites W2139002942 @default.
• W3081113055 cites W2151742889 @default.
• W3081113055 cites W2157517230 @default.
• W3081113055 cites W2165240086 @default.
• W3081113055 cites W2165913979 @default.
• W3081113055 cites W2168519960 @default.
• W3081113055 cites W2201379139 @default.
• W3081113055 cites W2321921989 @default.
• W3081113055 cites W2327138772 @default.
• W3081113055 cites W2556899512 @default.
• W3081113055 cites W2580313904 @default.
• W3081113055 cites W2585492454 @default.
• W3081113055 cites W2598197072 @default.
• W3081113055 cites W2613613983 @default.
• W3081113055 cites W2767929723 @default.
• W3081113055 cites W2773836103 @default.
• W3081113055 cites W2902147362 @default.
• W3081113055 cites W2970933602 @default.
• W3081113055 cites W2971362306 @default.
• W3081113055 cites W2983601658 @default.
• W3081113055 cites W2986401381 @default.
• W3081113055 cites W2991923022 @default.
• W3081113055 cites W2998692389 @default.
• W3081113055 cites W3128514367 @default.
• W3081113055 cites W4241169468 @default.
• W3081113055 cites W4249155082 @default.

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