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- W3081117110 abstract "Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitude, and a characteristic rebound and resolution of slow wave sleep-slow wave activity (SWS-SWA). However, the molecular mechanism(s) mediating the sleep-loss response are not well understood. We show that sleep-loss regulates MEF2C phosphorylation, a key mechanism regulating MEF2C transcriptional activity, and that MEF2C function in postnatal excitatory forebrain neurons is required for the biological events in response to sleep loss in C57BL/6J mice. These include altered gene expression, the increase and recovery of synaptic strength, and the rebound and resolution of SWS-SWA, which implicate MEF2C as an essential regulator of sleep function." @default.
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- W3081117110 date "2020-08-27" @default.
- W3081117110 modified "2023-09-27" @default.
- W3081117110 title "An essential role for MEF2C in the cortical response to loss of sleep in mice" @default.
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- W3081117110 doi "https://doi.org/10.7554/elife.58331" @default.
- W3081117110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7490011" @default.
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