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• W3081132357 abstract "The objective of this study was to develop an immediate release dose form containing 250 mg Mefenamic acid (MFA) presented as a crystalline solid dispersion in order to achieve improved consistency in drug release through a simplified formulation compared to a commercial product. An MFA-Soluplus®-Sorbitol polymer matrix was developed using an HME process based on rheological screening assays of physical mixtures. The physico-chemical properties of these formulations were assessed by thermal analysis, FTIR, mechanical testing and SEM image analysis, confirming the crystalline character and stable polymorphic form I of the API in the polymer matrix. A faster release and a significant improvement in consistency (±6%) of drug release was observed compared to a commercially available MFA product (±17%) (250 mg capsule). This study illustrates advantages of applying a structured development program aimed at retaining API physical properties in the final dosage form." @default.
• W3081132357 created "2020-09-01" @default.
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• W3081132357 date "2020-11-01" @default.
• W3081132357 modified "2023-10-15" @default.
• W3081132357 title "Improving Consistency for a Mefenamic Acid Immediate Release Formulation" @default.
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• W3081132357 doi "https://doi.org/10.1016/j.xphs.2020.08.012" @default.
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