FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081156004> ?p ?o ?g. }

• W3081156004 endingPage "111231" @default.
• W3081156004 startingPage "111231" @default.
• W3081156004 abstract "Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly understood. In the present study, Cd exposure activated mTORC1 in primary rat proximal tubular (rPT) cells, and two mTORC1 inhibitors (rapamycin and torin 1) were separately utilized to inhibit Cd-induced mTORC1 activation. Data showed that Cd-inhibited autophagic flux was markedly restored by two mTORC1 inhibitors, respectively, as evidenced by immunoblot analysis of autophagy marker proteins and tandem red fluorescent protein-green fluorescent protein-microtubule associated protein light chain 3 (RFP-GFP-LC3) fluorescence microscopy assay. Importantly, Cd exposure triggered the recruitment of mTORC1 onto lysosome membrane assessed by immunofluorescence co-localization analysis, which was obviously inhibited by rapamycin or torin 1. Moreover, Cd-induced lysosomal alkalization, suppressed vacuolar ATPases (V-ATPases) protein levels and impaired lysosomal degradation capacity were markedly reversed by rapamycin or torin 1. In summary, these findings demonstrate that Cd recruits mTORC1 to lysosome membrane to induce its activation, which results in lysosomal dysfunction and resultant autophagy inhibition in rPT cells." @default.
• W3081156004 created "2020-09-01" @default.
• W3081156004 creator A5013437001 @default.
• W3081156004 creator A5017599791 @default.
• W3081156004 creator A5019468096 @default.
• W3081156004 creator A5053275663 @default.
• W3081156004 creator A5063367264 @default.
• W3081156004 creator A5086144690 @default.
• W3081156004 date "2020-11-01" @default.
• W3081156004 modified "2023-10-16" @default.
• W3081156004 title "mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells" @default.
• W3081156004 cites W1855404173 @default.
• W3081156004 cites W1972949428 @default.
• W3081156004 cites W1973687895 @default.
• W3081156004 cites W1979783084 @default.
• W3081156004 cites W2003108613 @default.
• W3081156004 cites W2027785297 @default.
• W3081156004 cites W2031738820 @default.
• W3081156004 cites W2033453768 @default.
• W3081156004 cites W2034972226 @default.
• W3081156004 cites W2037109247 @default.
• W3081156004 cites W2047254740 @default.
• W3081156004 cites W2057187076 @default.
• W3081156004 cites W2063920469 @default.
• W3081156004 cites W2080015061 @default.
• W3081156004 cites W2098912234 @default.
• W3081156004 cites W2127063807 @default.
• W3081156004 cites W2157384163 @default.
• W3081156004 cites W2277796992 @default.
• W3081156004 cites W2531587038 @default.
• W3081156004 cites W2538301867 @default.
• W3081156004 cites W2598555903 @default.
• W3081156004 cites W2606755409 @default.
• W3081156004 cites W2623226106 @default.
• W3081156004 cites W2751139845 @default.
• W3081156004 cites W2756985996 @default.
• W3081156004 cites W2763311421 @default.
• W3081156004 cites W2766243612 @default.
• W3081156004 cites W2771826181 @default.
• W3081156004 cites W2791699550 @default.
• W3081156004 cites W2889189005 @default.
• W3081156004 cites W2890492307 @default.
• W3081156004 cites W2896455688 @default.
• W3081156004 cites W2906109165 @default.
• W3081156004 cites W2908182526 @default.
• W3081156004 cites W2913403930 @default.
• W3081156004 cites W2916591690 @default.
• W3081156004 cites W2953667727 @default.
• W3081156004 cites W2963387403 @default.
• W3081156004 cites W2969736513 @default.
• W3081156004 cites W2976229235 @default.
• W3081156004 cites W2979459757 @default.
• W3081156004 cites W3006763673 @default.
• W3081156004 cites W3012902531 @default.
• W3081156004 doi "https://doi.org/10.1016/j.jinorgbio.2020.111231" @default.
• W3081156004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32862047" @default.
• W3081156004 hasPublicationYear "2020" @default.
• W3081156004 type Work @default.
• W3081156004 sameAs 3081156004 @default.
• W3081156004 citedByCount "20" @default.
• W3081156004 countsByYear W30811560042021 @default.
• W3081156004 countsByYear W30811560042022 @default.
• W3081156004 countsByYear W30811560042023 @default.
• W3081156004 crossrefType "journal-article" @default.
• W3081156004 hasAuthorship W3081156004A5013437001 @default.
• W3081156004 hasAuthorship W3081156004A5017599791 @default.
• W3081156004 hasAuthorship W3081156004A5019468096 @default.
• W3081156004 hasAuthorship W3081156004A5053275663 @default.
• W3081156004 hasAuthorship W3081156004A5063367264 @default.
• W3081156004 hasAuthorship W3081156004A5086144690 @default.
• W3081156004 hasConcept C102568950 @default.
• W3081156004 hasConcept C104317684 @default.
• W3081156004 hasConcept C121332964 @default.
• W3081156004 hasConcept C142613039 @default.
• W3081156004 hasConcept C169274487 @default.
• W3081156004 hasConcept C181199279 @default.
• W3081156004 hasConcept C185592680 @default.
• W3081156004 hasConcept C190062978 @default.
• W3081156004 hasConcept C190283241 @default.
• W3081156004 hasConcept C203522944 @default.
• W3081156004 hasConcept C2777722557 @default.
• W3081156004 hasConcept C2780216420 @default.
• W3081156004 hasConcept C55493867 @default.
• W3081156004 hasConcept C62478195 @default.
• W3081156004 hasConcept C62520636 @default.
• W3081156004 hasConcept C86554907 @default.
• W3081156004 hasConcept C86803240 @default.
• W3081156004 hasConcept C91881484 @default.
• W3081156004 hasConcept C95444343 @default.
• W3081156004 hasConcept C98490376 @default.
• W3081156004 hasConceptScore W3081156004C102568950 @default.
• W3081156004 hasConceptScore W3081156004C104317684 @default.
• W3081156004 hasConceptScore W3081156004C121332964 @default.
• W3081156004 hasConceptScore W3081156004C142613039 @default.
• W3081156004 hasConceptScore W3081156004C169274487 @default.
• W3081156004 hasConceptScore W3081156004C181199279 @default.
• W3081156004 hasConceptScore W3081156004C185592680 @default.
• W3081156004 hasConceptScore W3081156004C190062978 @default.

• next