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- W3081159923 abstract "Type 2 diabetes (T2D) is a metabolic disease characterized by obesity, insulin resistance and the dysfunction of several key glucoregulatory organs. Among these organs, impaired liver function is recognized as one of the earliest contributors to impaired whole-body glucose homeostasis, with well characterized hepatic insulin resistance resulting in elevated rates of hepatic glucose production (HGP) and fasting hyperglycemia. One portion of this review will provide an overview of how HGP is regulated during the fasted state in healthy humans and how this process becomes dysregulated in patients with T2D. Less well appreciated is the liver’s role in postprandial glucose metabolism, where it takes up and metabolizes one-third of orally ingested glucose. An abundance of literature has shown that the process of hepatic glucose uptake is impaired in patients with T2D, thereby contributing to glucose intolerance. A second portion of this review will outline how hepatic glucose uptake is regulated during the postprandial state, and how it becomes dysfunctional in patients with T2D. On a positive note, it is well known that exercise training has an insulin-sensitizing effect on the liver, which contributes to improved whole-body glucose metabolism in T2D patients, thereby making it a cornerstone in the management of the disease. To this end, we thoroughly discuss the impact of exercise on hepatic glucose metabolism, referencing key findings in the literature. At the same time, we discuss sources of heterogeneity that contribute to inconsistent findings in the field and point out important topics for future investigation." @default.
- W3081159923 created "2020-09-01" @default.
- W3081159923 creator A5030293561 @default.
- W3081159923 creator A5057282120 @default.
- W3081159923 creator A5057425681 @default.
- W3081159923 creator A5079124923 @default.
- W3081159923 date "2020-08-28" @default.
- W3081159923 modified "2023-09-26" @default.
- W3081159923 title "Exercise-Induced Improvements to Whole Body Glucose Metabolism in Type 2 Diabetes: The Essential Role of the Liver" @default.
- W3081159923 cites W1481876517 @default.
- W3081159923 cites W1520359999 @default.
- W3081159923 cites W1598767975 @default.
- W3081159923 cites W1676164379 @default.
- W3081159923 cites W1859469442 @default.
- W3081159923 cites W1949566366 @default.
- W3081159923 cites W1964403046 @default.
- W3081159923 cites W1974498385 @default.
- W3081159923 cites W1975525226 @default.
- W3081159923 cites W1985548689 @default.
- W3081159923 cites W1987659907 @default.
- W3081159923 cites W1989002168 @default.
- W3081159923 cites W1996049375 @default.
- W3081159923 cites W1999199961 @default.
- W3081159923 cites W2001860046 @default.
- W3081159923 cites W2007316696 @default.
- W3081159923 cites W2009237205 @default.
- W3081159923 cites W2011378557 @default.
- W3081159923 cites W2011985622 @default.
- W3081159923 cites W2017032820 @default.
- W3081159923 cites W2018194733 @default.
- W3081159923 cites W2018492975 @default.
- W3081159923 cites W2022649084 @default.
- W3081159923 cites W2026823997 @default.
- W3081159923 cites W2031773477 @default.
- W3081159923 cites W2033891819 @default.
- W3081159923 cites W2041452817 @default.
- W3081159923 cites W2043131921 @default.
- W3081159923 cites W2047243213 @default.
- W3081159923 cites W2053915733 @default.
- W3081159923 cites W2054981406 @default.
- W3081159923 cites W2056293143 @default.
- W3081159923 cites W2056935382 @default.
- W3081159923 cites W2063560080 @default.
- W3081159923 cites W2067984172 @default.
- W3081159923 cites W2072354206 @default.
- W3081159923 cites W2072656195 @default.
- W3081159923 cites W2074366941 @default.
- W3081159923 cites W2077666699 @default.
- W3081159923 cites W2079497543 @default.
- W3081159923 cites W2093148822 @default.
- W3081159923 cites W2103348177 @default.
- W3081159923 cites W2105015731 @default.
- W3081159923 cites W2109728760 @default.
- W3081159923 cites W2111101384 @default.
- W3081159923 cites W2113278846 @default.
- W3081159923 cites W2113667153 @default.
- W3081159923 cites W2114669482 @default.
- W3081159923 cites W2117233341 @default.
- W3081159923 cites W2118639756 @default.
- W3081159923 cites W2124148220 @default.
- W3081159923 cites W2125537518 @default.
- W3081159923 cites W2125578565 @default.
- W3081159923 cites W2125989795 @default.
- W3081159923 cites W2127238518 @default.
- W3081159923 cites W2128282444 @default.
- W3081159923 cites W2130421055 @default.
- W3081159923 cites W2133397189 @default.
- W3081159923 cites W2134049755 @default.
- W3081159923 cites W2135311233 @default.
- W3081159923 cites W2136906985 @default.
- W3081159923 cites W2139034245 @default.
- W3081159923 cites W2140653555 @default.
- W3081159923 cites W2141697206 @default.
- W3081159923 cites W2142508843 @default.
- W3081159923 cites W2144651037 @default.
- W3081159923 cites W2145320282 @default.
- W3081159923 cites W2146118393 @default.
- W3081159923 cites W2148956702 @default.
- W3081159923 cites W2149587559 @default.
- W3081159923 cites W2150937124 @default.
- W3081159923 cites W2153401503 @default.
- W3081159923 cites W2153747727 @default.
- W3081159923 cites W2154069424 @default.
- W3081159923 cites W2157480658 @default.
- W3081159923 cites W2160591626 @default.
- W3081159923 cites W2162078153 @default.
- W3081159923 cites W2166602509 @default.
- W3081159923 cites W2167227928 @default.
- W3081159923 cites W2168929358 @default.
- W3081159923 cites W2168937351 @default.
- W3081159923 cites W2169051965 @default.
- W3081159923 cites W2169312890 @default.
- W3081159923 cites W2169401893 @default.
- W3081159923 cites W2174452576 @default.
- W3081159923 cites W2175091172 @default.
- W3081159923 cites W2186184337 @default.
- W3081159923 cites W2188889462 @default.
- W3081159923 cites W2255598688 @default.
- W3081159923 cites W2282569534 @default.
- W3081159923 cites W2292388834 @default.