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- W3081182275 endingPage "4893" @default.
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- W3081182275 abstract "The fragment docking program solvation energy for exhaustive docking (SEED) is evaluated on 15 different protein targets, with a focus on enrichment and the hit rate. It is shown that SEED allows for consistent computational enrichment of fragment libraries, independent of the effective hit rate. Depending on the actual target protein, true positive rates ranging up to 27% are observed at a cutoff value corresponding to the experimental hit rate. The impact of variations in docking protocols and energy filters is discussed in detail. Remaining issues, limitations, and use cases of SEED are also discussed. Our results show that fragment library selection or enhancement for a particular target is likely to benefit from docking with SEED, suggesting that SEED is a useful resource for fragment screening campaigns. A workflow is presented for the use of the program in virtual screening, including filtering and postprocessing to optimize hit rates." @default.
- W3081182275 created "2020-09-01" @default.
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- W3081182275 date "2020-08-21" @default.
- W3081182275 modified "2023-09-27" @default.
- W3081182275 title "Assessment of the Fragment Docking Program SEED" @default.
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- W3081182275 doi "https://doi.org/10.1021/acs.jcim.0c00556" @default.
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