FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081185405> ?p ?o ?g. }

• W3081185405 endingPage "13033" @default.
• W3081185405 startingPage "13025" @default.
• W3081185405 abstract "The recent development of an in vivo solid-phase microextraction (SPME) method capable of analyzing drugs and metabolic products in biofluids and living tissues holds great promise. The standard in vivo SPME protocol based on mass spectrometry is a very powerful analytical approach, but it is not practical for on-site analysis in many cases. In this paper, we present a fluorescence-based SPME method and a prototype of a portable fluorometer that is capable of quickly quantifying concentrations of the anticancer drug, doxorubicin (DOX). The instrument uses thin coated, biocompatible SPME fibers, which we have previously presented as a chemical biopsy tool for use during in vivo lung perfusion (IVLP) procedures within a hospital setting. In this research, we test SPME fibers with C8-SCX, C18, and HLB coatings with our fluorometer. The mixed-mode C8-SCX fibers showed the best sensitivity of the three and were therefore used to examine DOX extraction from perfusate solution and a homogenized lamb lung tissue. The maximum concentration of free active sites in the C8-SCX fiber and the adsorption equilibrium constant were determined to be (9.1 ± 0.3) × 10–7 mol m–2 and 420 ± 30 m3 mol–1, respectively. Finally, the detection limits for DOX extracted from buffer, perfusate, and lung tissue were 40, 100, and 3700 μg L–1, respectively." @default.
• W3081185405 created "2020-09-01" @default.
• W3081185405 creator A5022888470 @default.
• W3081185405 creator A5085384354 @default.
• W3081185405 date "2020-08-27" @default.
• W3081185405 modified "2023-10-17" @default.
• W3081185405 title "Fluorometer for Screening of Doxorubicin in Perfusate Solution and Tissue with Solid-Phase Microextraction Chemical Biopsy Sampling" @default.
• W3081185405 cites W1433242939 @default.
• W3081185405 cites W1507268847 @default.
• W3081185405 cites W1543790510 @default.
• W3081185405 cites W17122464 @default.
• W3081185405 cites W1966393407 @default.
• W3081185405 cites W1967846805 @default.
• W3081185405 cites W1968793804 @default.
• W3081185405 cites W1976704016 @default.
• W3081185405 cites W1983404425 @default.
• W3081185405 cites W1988950753 @default.
• W3081185405 cites W1990504585 @default.
• W3081185405 cites W1994442450 @default.
• W3081185405 cites W2001967831 @default.
• W3081185405 cites W2027578741 @default.
• W3081185405 cites W2029753193 @default.
• W3081185405 cites W2041176712 @default.
• W3081185405 cites W2046691728 @default.
• W3081185405 cites W2058470960 @default.
• W3081185405 cites W2083154121 @default.
• W3081185405 cites W2084405554 @default.
• W3081185405 cites W2087246411 @default.
• W3081185405 cites W2091704306 @default.
• W3081185405 cites W2123565275 @default.
• W3081185405 cites W2124568949 @default.
• W3081185405 cites W2128437651 @default.
• W3081185405 cites W2141176795 @default.
• W3081185405 cites W2289796594 @default.
• W3081185405 cites W2317055602 @default.
• W3081185405 cites W2330709470 @default.
• W3081185405 cites W2521143533 @default.
• W3081185405 cites W2528235455 @default.
• W3081185405 cites W2538141691 @default.
• W3081185405 cites W2554168993 @default.
• W3081185405 cites W2577990875 @default.
• W3081185405 cites W2600596288 @default.
• W3081185405 cites W2754844530 @default.
• W3081185405 cites W2755309086 @default.
• W3081185405 cites W2767489832 @default.
• W3081185405 cites W2789910888 @default.
• W3081185405 cites W2792166638 @default.
• W3081185405 cites W2914036267 @default.
• W3081185405 cites W2916495832 @default.
• W3081185405 cites W2918804050 @default.
• W3081185405 cites W2921101055 @default.
• W3081185405 cites W2945589655 @default.
• W3081185405 cites W3081919330 @default.
• W3081185405 cites W821127453 @default.
• W3081185405 doi "https://doi.org/10.1021/acs.analchem.0c01905" @default.
• W3081185405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32847350" @default.
• W3081185405 hasPublicationYear "2020" @default.
• W3081185405 type Work @default.
• W3081185405 sameAs 3081185405 @default.
• W3081185405 citedByCount "12" @default.
• W3081185405 countsByYear W30811854052021 @default.
• W3081185405 countsByYear W30811854052022 @default.
• W3081185405 countsByYear W30811854052023 @default.
• W3081185405 crossrefType "journal-article" @default.
• W3081185405 hasAuthorship W3081185405A5022888470 @default.
• W3081185405 hasAuthorship W3081185405A5085384354 @default.
• W3081185405 hasConcept C119128265 @default.
• W3081185405 hasConcept C121332964 @default.
• W3081185405 hasConcept C150903083 @default.
• W3081185405 hasConcept C162356407 @default.
• W3081185405 hasConcept C185592680 @default.
• W3081185405 hasConcept C202800777 @default.
• W3081185405 hasConcept C205345274 @default.
• W3081185405 hasConcept C207001950 @default.
• W3081185405 hasConcept C2778533135 @default.
• W3081185405 hasConcept C43617362 @default.
• W3081185405 hasConcept C62520636 @default.
• W3081185405 hasConcept C86803240 @default.
• W3081185405 hasConcept C91881484 @default.
• W3081185405 hasConceptScore W3081185405C119128265 @default.
• W3081185405 hasConceptScore W3081185405C121332964 @default.
• W3081185405 hasConceptScore W3081185405C150903083 @default.
• W3081185405 hasConceptScore W3081185405C162356407 @default.
• W3081185405 hasConceptScore W3081185405C185592680 @default.
• W3081185405 hasConceptScore W3081185405C202800777 @default.
• W3081185405 hasConceptScore W3081185405C205345274 @default.
• W3081185405 hasConceptScore W3081185405C207001950 @default.
• W3081185405 hasConceptScore W3081185405C2778533135 @default.
• W3081185405 hasConceptScore W3081185405C43617362 @default.
• W3081185405 hasConceptScore W3081185405C62520636 @default.
• W3081185405 hasConceptScore W3081185405C86803240 @default.
• W3081185405 hasConceptScore W3081185405C91881484 @default.
• W3081185405 hasFunder F4320334506 @default.
• W3081185405 hasFunder F4320334593 @default.
• W3081185405 hasIssue "19" @default.
• W3081185405 hasLocation W30811854051 @default.
• W3081185405 hasOpenAccess W3081185405 @default.
• W3081185405 hasPrimaryLocation W30811854051 @default.

• next