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• W3081225785 endingPage "102007" @default.
• W3081225785 startingPage "102007" @default.
• W3081225785 abstract "Peptide and protein drugs (PPDs) that possess the advantages of high specificity and tolerance, and low immunogenicity can effectively treat diabetes, osteoporosis, cancer, and genetic defects. However, the high molecular weight and poor stability of PPDs lead to low bioavailability in oral delivery of these drugs and poor compliance of patients with subcutaneous injection, which greatly limit their clinical applications. Transdermal drug delivery has the characters of low invasiveness, low cost and simple operation, and it is easy to implement self-management of patients, reduce the risk of infection, and improve compliance of patients. However, the transdermal delivery of hydrophilic and macromolecular PPDs is difficult to penetrate the barrier of the stratum corneum. Recently, various novel strategies have been developed for percutaneous delivery of PPDs to the systemic circulation, which are summarized in this review. The mechanism, advantages and limitations of these strategies are also discussed." @default.
• W3081225785 created "2020-09-01" @default.
• W3081225785 creator A5017743340 @default.
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• W3081225785 creator A5037583548 @default.
• W3081225785 creator A5045818662 @default.
• W3081225785 creator A5053549156 @default.
• W3081225785 creator A5070583353 @default.
• W3081225785 date "2020-12-01" @default.
• W3081225785 modified "2023-10-18" @default.
• W3081225785 title "Transdermal delivery of peptide and protein drugs: Strategies, advantages and disadvantages" @default.
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