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- W3081226105 abstract "Abstract Cariogenic Streptococcus mutans is known as a predominant etiological agent of dental caries due to its exceptional capacity in forming biofilms. From strains of S. mutans isolated from dental plaque, we here discover a polyketide/non-ribosomal peptide biosynthetic gene cluster, muf , which directly correlates with a strong biofilm-forming capability. We then identify the muf -associated bioactive product, mutanofactin-697 that contains a novel molecular scaffold, along with its biosynthetic logic. Further mode-of-action studies reveal mutanofactin-697 binds to S. mutans cells nonspecifically, increases bacterial hydrophobicity, and promotes bacterial adhesion and subsequent biofilm formation. Our findings provide the first example of a microbial secondary metabolite promoting biofilm formation via a physicochemical approach, highlighting the significance of secondary metabolism in mediating critical processes related to the development of dental caries." @default.
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- W3081226105 date "2020-08-23" @default.
- W3081226105 modified "2023-09-30" @default.
- W3081226105 title "Mutanofactin promotes bacterial adhesion and biofilm formation of cariogenic <i>Streptococcus mutans</i>" @default.
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- W3081226105 doi "https://doi.org/10.1101/2020.08.22.262196" @default.
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