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- W3081230922 endingPage "110992" @default.
- W3081230922 startingPage "110992" @default.
- W3081230922 abstract "The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase (PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and two catalytic (PKA-C) subunits. The PKA-R subunits act as sensors of cAMP and allow PKA-C activity. One of the first signaling events observed during mammalian sperm capacitation is PKA activation. Thus, understanding how PKA activity is restricted in space and time is crucial to decipher the critical steps of sperm capacitation. It is widely accepted that PKA specificity depends on several levels of regulation. Anchoring proteins play a pivotal role in achieving proper localization signaling, subcellular targeting and cAMP microdomains. These multi-factorial regulation steps are necessary for a precise spatio-temporal activation of PKA. Here we discuss recent understanding of regulatory mechanisms of PKA in mammalian sperm, such as post-translational modifications, in the context of its role as the master orchestrator of molecular events conducive to capacitation." @default.
- W3081230922 created "2020-09-01" @default.
- W3081230922 creator A5016497460 @default.
- W3081230922 creator A5027909019 @default.
- W3081230922 creator A5033068410 @default.
- W3081230922 creator A5050699564 @default.
- W3081230922 creator A5074606904 @default.
- W3081230922 creator A5085965055 @default.
- W3081230922 creator A5086091949 @default.
- W3081230922 date "2020-12-01" @default.
- W3081230922 modified "2023-10-16" @default.
- W3081230922 title "Everything you ever wanted to know about PKA regulation and its involvement in mammalian sperm capacitation" @default.
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