FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081282712> ?p ?o ?g. }

• W3081282712 endingPage "2608" @default.
• W3081282712 startingPage "2608" @default.
• W3081282712 abstract "Background. Vitamin D deficiency represents a major healthcare problem. Vitamin D status is influenced by genetic and environmental determinants. Several observational studies have evaluated the association of single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and vitamin D levels. Nevertheless, little is known about the role of these SNPs in the response to vitamin D supplementation. We conducted an interventional study to define the association between SNPs in vitamin D-related genes and the response to vitamin D supplementation in 100 self-reported healthy women of Arab ancestry for the majority. Methods. A total of 100 healthy female subjects received a weekly oral dose of 50,000 IU vitamin D for 12 weeks. Serum vitamin D concentration and metabolic profiles were measured at baseline and 12 weeks post-vitamin D supplementation. The genotypes of 37 SNPs selected from previously reported vitamin D-related genes have been assessed by Fluidigm genotyping assay. Results. Rs731236 (VDR gene) and rs7116978 (CYP2R1 gene) showed a significant association with vitamin D status. The rs731236 GG genotype and the rs7116978 CC genotype were associated with a “vitamin D sufficiency” state. Rs731236 GG and rs7116978 CC genotypes showed a higher response to vitamin D supplementation. Transcription factor binding site prediction analysis showed altered binding sites for transcription factors according to the different rs7116978 alleles. Interestingly, the 37 SNPs previously established to play a role in vitamin D-related pathways explained very little of the response to vitamin D supplementation in our cohort, suggesting the existence of alternative loci whose number and effect size need to be investigated in future studies. Conclusion. In this paper, we present novel data on vitamin D-related SNPs and response to vitamin D supplementation demonstrating the feasibility of applying functional genomic approaches in interventional studies to assess individual-level responses to vitamin D supplementation." @default.
• W3081282712 created "2020-09-01" @default.
• W3081282712 creator A5015101639 @default.
• W3081282712 creator A5018039050 @default.
• W3081282712 creator A5021968833 @default.
• W3081282712 creator A5025308944 @default.
• W3081282712 creator A5027980180 @default.
• W3081282712 creator A5029681923 @default.
• W3081282712 creator A5037642030 @default.
• W3081282712 creator A5048769007 @default.
• W3081282712 date "2020-08-27" @default.
• W3081282712 modified "2023-09-24" @default.
• W3081282712 title "The Role of Polymorphisms in Vitamin D-Related Genes in Response to Vitamin D Supplementation" @default.
• W3081282712 cites W1589100385 @default.
• W3081282712 cites W1896055237 @default.
• W3081282712 cites W1969887669 @default.
• W3081282712 cites W1971229919 @default.
• W3081282712 cites W1974092422 @default.
• W3081282712 cites W1974366534 @default.
• W3081282712 cites W1986903987 @default.
• W3081282712 cites W1994141684 @default.
• W3081282712 cites W2000610553 @default.
• W3081282712 cites W2003593645 @default.
• W3081282712 cites W2009307285 @default.
• W3081282712 cites W2015843401 @default.
• W3081282712 cites W2016448652 @default.
• W3081282712 cites W2019699779 @default.
• W3081282712 cites W2031406513 @default.
• W3081282712 cites W2054877919 @default.
• W3081282712 cites W2055480626 @default.
• W3081282712 cites W2066403429 @default.
• W3081282712 cites W2068081568 @default.
• W3081282712 cites W2068164341 @default.
• W3081282712 cites W2076052616 @default.
• W3081282712 cites W2082019333 @default.
• W3081282712 cites W2086127231 @default.
• W3081282712 cites W2086690571 @default.
• W3081282712 cites W2096069238 @default.
• W3081282712 cites W2099820266 @default.
• W3081282712 cites W2112345914 @default.
• W3081282712 cites W2113603970 @default.
• W3081282712 cites W2114849059 @default.
• W3081282712 cites W2116660030 @default.
• W3081282712 cites W2124070987 @default.
• W3081282712 cites W2139840047 @default.
• W3081282712 cites W2139999609 @default.
• W3081282712 cites W2147614107 @default.
• W3081282712 cites W2153059487 @default.
• W3081282712 cites W2157698829 @default.
• W3081282712 cites W2162258804 @default.
• W3081282712 cites W2162530578 @default.
• W3081282712 cites W2164882053 @default.
• W3081282712 cites W2164976842 @default.
• W3081282712 cites W2171407623 @default.
• W3081282712 cites W2460865604 @default.
• W3081282712 cites W2468708740 @default.
• W3081282712 cites W2483939391 @default.
• W3081282712 cites W2488763497 @default.
• W3081282712 cites W2521745537 @default.
• W3081282712 cites W2587942829 @default.
• W3081282712 cites W2616730536 @default.
• W3081282712 cites W2780162225 @default.
• W3081282712 cites W2791766408 @default.
• W3081282712 cites W2796780444 @default.
• W3081282712 cites W2800439408 @default.
• W3081282712 cites W2884274719 @default.
• W3081282712 cites W2888916792 @default.
• W3081282712 cites W2902563677 @default.
• W3081282712 cites W2917026717 @default.
• W3081282712 cites W2944075108 @default.
• W3081282712 cites W2971867263 @default.
• W3081282712 cites W2976364525 @default.
• W3081282712 cites W4211046201 @default.
• W3081282712 doi "https://doi.org/10.3390/nu12092608" @default.
• W3081282712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7551134" @default.
• W3081282712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32867112" @default.
• W3081282712 hasPublicationYear "2020" @default.
• W3081282712 type Work @default.
• W3081282712 sameAs 3081282712 @default.
• W3081282712 citedByCount "12" @default.
• W3081282712 countsByYear W30812827122021 @default.
• W3081282712 countsByYear W30812827122022 @default.
• W3081282712 countsByYear W30812827122023 @default.
• W3081282712 crossrefType "journal-article" @default.
• W3081282712 hasAuthorship W3081282712A5015101639 @default.
• W3081282712 hasAuthorship W3081282712A5018039050 @default.
• W3081282712 hasAuthorship W3081282712A5021968833 @default.
• W3081282712 hasAuthorship W3081282712A5025308944 @default.
• W3081282712 hasAuthorship W3081282712A5027980180 @default.
• W3081282712 hasAuthorship W3081282712A5029681923 @default.
• W3081282712 hasAuthorship W3081282712A5037642030 @default.
• W3081282712 hasAuthorship W3081282712A5048769007 @default.
• W3081282712 hasBestOaLocation W30812827121 @default.
• W3081282712 hasConcept C104317684 @default.
• W3081282712 hasConcept C124490489 @default.
• W3081282712 hasConcept C126322002 @default.
• W3081282712 hasConcept C134018914 @default.
• W3081282712 hasConcept C135763542 @default.

• next