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• W3081301622 startingPage "2873" @default.
• W3081301622 abstract "Multicomponent reactions (MCRs) as a green strategy was used to crosslink carboxymethylcellulose (CMC) via the construction of bioactive carboxamide skeletons for the gentamicin (GM) oral delivery. The prepared multicomponent-crosslinked (MCC) CMC hydrogels (CMC-MCC) were fully characterized using various methods. To explain the productivity of the prepared system, GM delivery tests performed in the simulated gastrointestinal tract (GIT) conditions. CMC-MCC could efficiently protect the loaded-GM against the acidic environment of the stomach and enhance the sustainability of drug dosing with controlling the releases in the GIT circumstances. The antibacterial performance showed that the GM-loaded CMC-MCC has notable activity against S. aureus and E. coli bacteria. Besides, the cytotoxicity study indicated that CMC-MCC toward healthy normal human umbilical vein endothelial cells (HUVEC) has a cytocompatibility nature." @default.
• W3081301622 created "2020-09-01" @default.
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• W3081301622 date "2020-12-01" @default.
• W3081301622 modified "2023-10-18" @default.
• W3081301622 title "Green one-pot synthesis of multicomponent-crosslinked carboxymethyl cellulose as a safe carrier for the gentamicin oral delivery" @default.
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• W3081301622 doi "https://doi.org/10.1016/j.ijbiomac.2020.08.168" @default.
• W3081301622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32853613" @default.
• W3081301622 hasPublicationYear "2020" @default.
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