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- W3081330332 endingPage "112882" @default.
- W3081330332 startingPage "112882" @default.
- W3081330332 abstract "Traumatic brain injury (TBI) is one of the most prevalent injuries in the military with mild traumatic brain injury (mTBI) accounting for approximately 70–80 % of all TBI. TBI has been associated with diffuse and focal brain changes to structures and networks underlying cognitive-emotional processing. Although the anterior cingulate cortex (ACC) plays a critical role in emotion regulation and executive function and is susceptible to mTBI, studies focusing on ACC resting state functional connectivity (rs-fc) in Veterans are limited. Veterans with mTBI (n = 49) and with no history of TBI (n = 25), ages 20–54 completed clinical assessments and an 8-minute resting state functional magnetic resonance imaging (rs-fMRI) on a 3 T Siemens scanner. Imaging results were analyzed with left and right ACC as seed regions using SPM8. Regression analyses were performed with time since injury. Seed-based analysis showed increased connectivity of the left and right ACC with brain regions including middle and posterior cingulate regions, preceneus, and occipital regions in the mTBI compared to the non-TBI group. The rs-fMRI results indicate hyperconnectivity in Veterans with mTBI. These results are consistent with previous studies of recently concussed athletes showing ACC hyperconnectivity. Enhanced top-down control of attention networks necessary to compensate for the microstructural damage following mTBI may explain ACC hyperconnectivity post-mTBI." @default.
- W3081330332 created "2020-09-01" @default.
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- W3081330332 date "2021-01-01" @default.
- W3081330332 modified "2023-10-03" @default.
- W3081330332 title "Functional connectivity of the anterior cingulate cortex in Veterans with mild traumatic brain injury" @default.
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- W3081330332 doi "https://doi.org/10.1016/j.bbr.2020.112882" @default.
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