Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081374635> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3081374635 endingPage "185" @default.
- W3081374635 startingPage "175" @default.
- W3081374635 abstract "AMP-activated protein kinase (AMPK) is a metabolic master switch that has critical role in wide range of pathologies including cardiovascular disorders. As AMPK-α2 knockout mice exhibit impaired thrombus stability, we asked whether pharmacological inhibition of AMPK with a specific small-molecule inhibitor, compound C, could protect against arterial thrombosis without affecting hemostasis. Mice pre-administered with compound C exhibited decreased mesenteric arteriolar thrombosis but normal tail bleeding time compared to vehicle-treated animals. Compound C potently restricted platelet aggregation, clot retraction and integrin activation induced by thrombin and collagen. It impaired platelet spreading on both immobilized fibrinogen and collagen matrices; it, however, had no significant effect on thrombin-induced phosphatidylserine exposure that is characteristic of procoagulant platelets. In parallel, compound C brought about significant drop in thrombin-induced phosphorylation of myosin light chain (MLC) and MLC phosphatase (MYPT1) as well as abrogated rise in level of RhoA-GTP in thrombin-stimulated platelets. Thus, effects of compound C on agonist-induced platelet responses could be at least in part attributed to modulation of cytoskeletal changes mediated by RhoA-MYPT1-MLC signaling. An ideal antithrombotic drug would spare hemostatic responses that maintain vascular integrity while preferentially protecting against thrombosis. The present study suggests that AMPK could be one such potential therapeutic target." @default.
- W3081374635 created "2020-09-01" @default.
- W3081374635 creator A5053879537 @default.
- W3081374635 creator A5056260151 @default.
- W3081374635 creator A5058050947 @default.
- W3081374635 creator A5065586922 @default.
- W3081374635 date "2020-12-01" @default.
- W3081374635 modified "2023-10-13" @default.
- W3081374635 title "AMPK inhibition protects against arterial thrombosis while sparing hemostasis through differential modulation of platelet responses" @default.
- W3081374635 cites W133668382 @default.
- W3081374635 cites W1881831871 @default.
- W3081374635 cites W1895802579 @default.
- W3081374635 cites W1969826031 @default.
- W3081374635 cites W1971095341 @default.
- W3081374635 cites W1978763812 @default.
- W3081374635 cites W1983760732 @default.
- W3081374635 cites W2005464779 @default.
- W3081374635 cites W2009390379 @default.
- W3081374635 cites W2022630818 @default.
- W3081374635 cites W2026535174 @default.
- W3081374635 cites W2027695011 @default.
- W3081374635 cites W2029925670 @default.
- W3081374635 cites W2030636484 @default.
- W3081374635 cites W2069384743 @default.
- W3081374635 cites W2075167858 @default.
- W3081374635 cites W2080107084 @default.
- W3081374635 cites W2088315278 @default.
- W3081374635 cites W2095063450 @default.
- W3081374635 cites W2114825009 @default.
- W3081374635 cites W2117100410 @default.
- W3081374635 cites W2138226825 @default.
- W3081374635 cites W2140460285 @default.
- W3081374635 cites W2143442358 @default.
- W3081374635 cites W2150551377 @default.
- W3081374635 cites W2159739693 @default.
- W3081374635 cites W2889371027 @default.
- W3081374635 cites W2898761605 @default.
- W3081374635 cites W2899467514 @default.
- W3081374635 cites W2948164341 @default.
- W3081374635 doi "https://doi.org/10.1016/j.thromres.2020.08.033" @default.
- W3081374635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32890901" @default.
- W3081374635 hasPublicationYear "2020" @default.
- W3081374635 type Work @default.
- W3081374635 sameAs 3081374635 @default.
- W3081374635 citedByCount "4" @default.
- W3081374635 countsByYear W30813746352022 @default.
- W3081374635 countsByYear W30813746352023 @default.
- W3081374635 crossrefType "journal-article" @default.
- W3081374635 hasAuthorship W3081374635A5053879537 @default.
- W3081374635 hasAuthorship W3081374635A5056260151 @default.
- W3081374635 hasAuthorship W3081374635A5058050947 @default.
- W3081374635 hasAuthorship W3081374635A5065586922 @default.
- W3081374635 hasConcept C126322002 @default.
- W3081374635 hasConcept C134018914 @default.
- W3081374635 hasConcept C185592680 @default.
- W3081374635 hasConcept C2777015399 @default.
- W3081374635 hasConcept C2777093181 @default.
- W3081374635 hasConcept C2777292125 @default.
- W3081374635 hasConcept C2778589496 @default.
- W3081374635 hasConcept C2778863912 @default.
- W3081374635 hasConcept C3018697912 @default.
- W3081374635 hasConcept C55493867 @default.
- W3081374635 hasConcept C62478195 @default.
- W3081374635 hasConcept C71924100 @default.
- W3081374635 hasConcept C89560881 @default.
- W3081374635 hasConcept C98274493 @default.
- W3081374635 hasConceptScore W3081374635C126322002 @default.
- W3081374635 hasConceptScore W3081374635C134018914 @default.
- W3081374635 hasConceptScore W3081374635C185592680 @default.
- W3081374635 hasConceptScore W3081374635C2777015399 @default.
- W3081374635 hasConceptScore W3081374635C2777093181 @default.
- W3081374635 hasConceptScore W3081374635C2777292125 @default.
- W3081374635 hasConceptScore W3081374635C2778589496 @default.
- W3081374635 hasConceptScore W3081374635C2778863912 @default.
- W3081374635 hasConceptScore W3081374635C3018697912 @default.
- W3081374635 hasConceptScore W3081374635C55493867 @default.
- W3081374635 hasConceptScore W3081374635C62478195 @default.
- W3081374635 hasConceptScore W3081374635C71924100 @default.
- W3081374635 hasConceptScore W3081374635C89560881 @default.
- W3081374635 hasConceptScore W3081374635C98274493 @default.
- W3081374635 hasLocation W30813746351 @default.
- W3081374635 hasOpenAccess W3081374635 @default.
- W3081374635 hasPrimaryLocation W30813746351 @default.
- W3081374635 hasRelatedWork W1549415843 @default.
- W3081374635 hasRelatedWork W2005464779 @default.
- W3081374635 hasRelatedWork W2050549532 @default.
- W3081374635 hasRelatedWork W2074420281 @default.
- W3081374635 hasRelatedWork W2103888323 @default.
- W3081374635 hasRelatedWork W2260044682 @default.
- W3081374635 hasRelatedWork W2287829455 @default.
- W3081374635 hasRelatedWork W2461840145 @default.
- W3081374635 hasRelatedWork W2734942203 @default.
- W3081374635 hasRelatedWork W2807545356 @default.
- W3081374635 hasVolume "196" @default.
- W3081374635 isParatext "false" @default.
- W3081374635 isRetracted "false" @default.
- W3081374635 magId "3081374635" @default.
- W3081374635 workType "article" @default.