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- W3081374706 abstract "Abstract The direct cleavage of C(CO)−C single bonds, delivering otherwise inaccessible compounds, is a significant challenge. Although the transition metal-catalyzed insertion of functional groups into C(CO)−C bonds has been studied, strained ketone substrates or chelating assistance were commonly required. In this article, we describe a rhodium(II)-catalyzed three-component reaction of 1,3-diones, diazoesters, and N,N -dimethylformamide (DMF), leading to an unusual formal insertion of O–C(sp 3 )–C(sp 2 ) into unstrained C(CO)−C bonds. This procedure provides a rapid entry to a gamut of otherwise inaccessible α,α,α-trisubstituted esters/amide from relatively simple substrates in a straightforward manner. 55 examples of highly decorated products demonstrate the broad functional group tolerance and substrate scope. The combination of control experiments and isotope-labeling reactions support that O, C(sp 3 ), and C(sp 2 ) units derive from 1,3-diones, diazoesters, and DMF, respectively." @default.
- W3081374706 created "2020-09-01" @default.
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- W3081374706 date "2020-08-24" @default.
- W3081374706 modified "2023-10-01" @default.
- W3081374706 title "Rhodium(II)-catalyzed multicomponent assembly of α,α,α-trisubstituted esters via formal insertion of O–C(sp3)–C(sp2) into C–C bonds" @default.
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- W3081374706 doi "https://doi.org/10.1038/s41467-020-17990-z" @default.
- W3081374706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7445163" @default.
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