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• W3081383640 abstract "Aim: The aim of this study is to prepare and characterize simvastatin-loaded nanoemulsions (SIM-LN) as well as evaluate their physicochemical properties and toxicity. Methodology & results: The SIM-LN were prepared, their characteristics evaluated for 30 days, and after that, the SIM-LN toxicity was evaluated using Vero cell culture and the in vivo model of Caenorhabditis elegans. The prepared SIM-LN had an average droplet size of 139 ± 22 nm, with high encapsulation rate (>98.4%). The storage at room temperature proved to be the most optimal condition. Toxicity assays demonstrated no toxicity. Conclusion: It was demonstrated that the surfactants used as emulsifiers optimized the properties without side effects, because no toxicity was measured in preliminary tests." @default.
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• W3081383640 date "2020-08-01" @default.
• W3081383640 modified "2023-10-16" @default.
• W3081383640 title "Simvastatin-loaded nanoemulsions: development, characterization, stability study and toxicity assays" @default.
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• W3081383640 doi "https://doi.org/10.4155/tde-2020-0067" @default.
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