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- W3081444644 abstract "Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylases, Sirt3 has also been documented to mediate nuclear gene expression, metabolic control, neuroprotection, cell cycle and proliferation. In ovarian cancer (OC), Sirt3 has been reported to regulate cellular metabolism, apoptosis and autophagy. Sirt3 can regulate autophagy through a variety of different molecular signaling pathways, including the p62, 5'AMP-activated protein kinase and mitochondrial ROS-superoxide dismutase pathways. However, autophagy downstream of Sirt3 and its association with OC remains poorly understood. In the present review, the known characteristics of Sirt3 and autophagy were outlined, and their potential functional roles were discussed. Following a comprehensive analysis of the current literature, Sirt3 and autophagy may either serve positive or negative roles in the regulation of OC. Therefore, it is important to identify the appropriate expression level of Sirt3 to control the activation of autophagy in OC cells. This strategy may prove to be a novel therapeutic method to reduce the mortality of patients with OC. Finally, potential research directions into the association between Sirt3 and other signaling pathways were provided." @default.
- W3081444644 created "2020-09-01" @default.
- W3081444644 creator A5005013207 @default.
- W3081444644 creator A5015397702 @default.
- W3081444644 creator A5018540311 @default.
- W3081444644 creator A5021711298 @default.
- W3081444644 creator A5061718211 @default.
- W3081444644 creator A5083275492 @default.
- W3081444644 date "2020-08-26" @default.
- W3081444644 modified "2023-10-11" @default.
- W3081444644 title "Potential relationship between Sirt3 and autophagy in ovarian cancer (Review)" @default.
- W3081444644 cites W1523693806 @default.
- W3081444644 cites W1606861223 @default.
- W3081444644 cites W1948872103 @default.
- W3081444644 cites W1970060454 @default.
- W3081444644 cites W1970637701 @default.
- W3081444644 cites W1974428745 @default.
- W3081444644 cites W1980458708 @default.
- W3081444644 cites W1985834536 @default.
- W3081444644 cites W1987963920 @default.
- W3081444644 cites W1989605865 @default.
- W3081444644 cites W2001568034 @default.
- W3081444644 cites W2005789183 @default.
- W3081444644 cites W2007846718 @default.
- W3081444644 cites W2009284352 @default.
- W3081444644 cites W2014965592 @default.
- W3081444644 cites W2034561234 @default.
- W3081444644 cites W2038007890 @default.
- W3081444644 cites W2044874695 @default.
- W3081444644 cites W2046250764 @default.
- W3081444644 cites W2046405298 @default.
- W3081444644 cites W2049753398 @default.
- W3081444644 cites W2052751736 @default.
- W3081444644 cites W2057530007 @default.
- W3081444644 cites W2063666824 @default.
- W3081444644 cites W2066030465 @default.
- W3081444644 cites W2066800765 @default.
- W3081444644 cites W2068136919 @default.
- W3081444644 cites W2068289009 @default.
- W3081444644 cites W2068347855 @default.
- W3081444644 cites W2075058338 @default.
- W3081444644 cites W2076293231 @default.
- W3081444644 cites W2081920342 @default.
- W3081444644 cites W2083230124 @default.
- W3081444644 cites W2084708023 @default.
- W3081444644 cites W2087861588 @default.
- W3081444644 cites W2092321143 @default.
- W3081444644 cites W2092897692 @default.
- W3081444644 cites W2101428185 @default.
- W3081444644 cites W2102353246 @default.
- W3081444644 cites W2111452131 @default.
- W3081444644 cites W2115742883 @default.
- W3081444644 cites W2115950845 @default.
- W3081444644 cites W2116755440 @default.
- W3081444644 cites W2119515848 @default.
- W3081444644 cites W2130130572 @default.
- W3081444644 cites W2133727193 @default.
- W3081444644 cites W2134354168 @default.
- W3081444644 cites W2139987952 @default.
- W3081444644 cites W2140912399 @default.
- W3081444644 cites W2141820814 @default.
- W3081444644 cites W2142093242 @default.
- W3081444644 cites W2148803450 @default.
- W3081444644 cites W2150026213 @default.
- W3081444644 cites W2150027419 @default.
- W3081444644 cites W2157699677 @default.
- W3081444644 cites W2159754384 @default.
- W3081444644 cites W2167592268 @default.
- W3081444644 cites W2167656141 @default.
- W3081444644 cites W2202885221 @default.
- W3081444644 cites W2243437543 @default.
- W3081444644 cites W2276472081 @default.
- W3081444644 cites W2395565369 @default.
- W3081444644 cites W2410249776 @default.
- W3081444644 cites W2416795960 @default.
- W3081444644 cites W2473773213 @default.
- W3081444644 cites W2563703915 @default.
- W3081444644 cites W2589716688 @default.
- W3081444644 cites W2598432420 @default.
- W3081444644 cites W2605111213 @default.
- W3081444644 cites W2612482748 @default.
- W3081444644 cites W2614409692 @default.
- W3081444644 cites W2616761213 @default.
- W3081444644 cites W2624817122 @default.
- W3081444644 cites W2625887862 @default.
- W3081444644 cites W2685284983 @default.
- W3081444644 cites W2738996050 @default.
- W3081444644 cites W2756212562 @default.
- W3081444644 cites W2758254154 @default.
- W3081444644 cites W2770305738 @default.
- W3081444644 cites W2778428046 @default.
- W3081444644 cites W2789397582 @default.
- W3081444644 cites W2789814858 @default.
- W3081444644 cites W2790027808 @default.
- W3081444644 cites W2794491744 @default.
- W3081444644 cites W2807649309 @default.
- W3081444644 cites W2808021744 @default.
- W3081444644 cites W2884327079 @default.