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- W3081457789 abstract "Objective: To evaluate the odds of death and poor discharge status among inpatients diagnosed with ischemic stroke (IS) with or without obstructive sleep apnea (OSA). Background: Hypoxic preconditioning has been demonstrated to induce stroke tolerance in mice. Patients with OSA have intermittent hypoxia; this may be a form of hypoxic preconditioning, and OSA patients may have better outcomes. Design/Methods: We used the Healthcare Cost and Utilization Project (HCUP) 2007 to 2009 inpatient database, which is an administrative database that uses ICD-9 codes to determine diagnoses, such as SAH and OSA. Unadjusted and adjusted logistic regressions were used to estimate the odds ratio and 95% confidence intervals for the association of OSA with mortality and poor discharge status. Good discharge status was defined as a discharge to home or acute rehab. Poor discharge status was defined as a discharge to a skilled nursing facility, intermediate care facility, another type of facility, or home health; departure against medical advice; or death. Results: A total of 134,399 patients with ischemic stroke was identified; 1,960 patients had OSA; 132,439 patients did not have OSA. In an unadjusted model, OSA was associated with lower odds of death [OR(95%CI) 0.52(0.41–0.65)]. After adjusting for obesity, age, sex, race, insurance, hypertension, and diabetes mellitus (DM), OSA remained associated with lower odds of death [OR(95%CI) 0.61(0.48–0.78)]. OSA was also associated with lower odds of poor discharge status in an unadjusted model [OR(95%CI) 0.620(0.541–0.711)]. After adjusting for obesity, age, sex, race, insurance, hypertension and DM, OSA was associated with lower odds of poor discharge status [OR(95%CI) 0.83(0.72–0.97)]. Conclusions: Among inpatients diagnosed with IS, OSA was associated with lower odds of death and poor discharge status. Consistent with animal studies, ischemic preconditioning could be a mechanism by which OSA leads to better outcomes after stroke in humans. Disclosure: Dr. Low has nothing to disclose. Dr. Elkind has received personal compensation in an editorial capacity for Neurology." @default.
- W3081457789 created "2020-09-01" @default.
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- W3081457789 date "2017-04-18" @default.
- W3081457789 modified "2023-09-26" @default.
- W3081457789 title "Obstructive Sleep Apnea is Associated with Improved Ischemic Stroke Outcomes (P4.312)" @default.
- W3081457789 hasPublicationYear "2017" @default.
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