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• W3081464498 endingPage "1227" @default.
• W3081464498 startingPage "1209" @default.
• W3081464498 abstract "Abstract A functional gradient has been proposed across the medial temporal lobes (MTL) such that the anterior MTL is thought to support processing of individual items (e.g., item memory and complex object perception), whereas the posterior MTL is thought to support item‐context retrieval (e.g., source memory). Whereas functional imaging studies have provided evidence supporting this anatomical organization, results from structural analyses remain inconclusive. The current study examined the relationship between volume of MTL regions of interest (ROIs), and performance on a source memory task and a fine‐grain complex object perception task, in healthy young adults (mean age = 21.5, range = 18–29). Using a semiautomated procedure, we segmented the parahippocampal and perirhinal cortices (PHC, PRC), posteromedial and anterolateral entorhinal cortices (pmERC, alERC), and posterior and anterior hippocampus (postHC, antHC) on high‐resolution T2‐weighted MRIs. Regional volumes were computed as proportions of intracranial volume, and as posterior–anterior volumetric ratios (PHC:PRC, pmERC:alERC, postHC:antHC). Partial‐least squares regressions were applied to predict source and item memory, and perceptual discrimination accuracy, based on ROI and ratio volumes. In our ROI regressions, we found that postHC volume was positively correlated with a latent factor predicting source memory, and PRC and antHC volumes were negatively correlated to this latent factor. In our ratio regressions, we observed an effect relating the posterior–anterior distribution of gray matter across the MTL with source memory. Our results demonstrate differential associations between anterior and posterior MTL and source memory performance. Findings from this study highlight the importance of considering patterns of structure–behavior associations in the neurobiology of episodic memory." @default.
• W3081464498 created "2020-09-01" @default.
• W3081464498 creator A5023713947 @default.
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• W3081464498 creator A5075025118 @default.
• W3081464498 creator A5086480795 @default.
• W3081464498 date "2020-08-24" @default.
• W3081464498 modified "2023-10-01" @default.
• W3081464498 title "The ratio of posterior–anterior medial temporal lobe volumes predicts source memory performance in healthy young adults" @default.
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