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- W3081471898 abstract "The default mode network (DMN) is a principal brain network in the mammalian brain. Although the DMN in humans has been extensively studied with respect to network structure, function, and clinical implications, our knowledge of DMN in animals remains limited. In particular, the functional role of DMN nodes, and how DMN organization relates to DMN-relevant behavior are still elusive. Here we investigated the causal relationship of inactivating a pivotal node of DMN (i.e., dorsal anterior cingulate cortex [dACC]) on DMN function, network organization, and behavior by combining chemogenetics, resting-state functional magnetic resonance imaging (rsfMRI) and behavioral tests in awake rodents. We found that suppressing dACC activity profoundly changed the activity and connectivity of DMN, and these changes were associated with altered DMN-related behavior in animals. The chemo-rsfMRI-behavior approach opens an avenue to mechanistically dissecting the relationships between a specific node, brain network function, and behavior. Our data suggest that, like in humans, DMN in rodents is a functional network with coordinated activity that mediates behavior." @default.
- W3081471898 created "2020-09-01" @default.
- W3081471898 creator A5004427603 @default.
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- W3081471898 date "2020-08-20" @default.
- W3081471898 modified "2023-10-01" @default.
- W3081471898 title "Suppressing Anterior Cingulate Cortex Modulates Default Mode Network and Behavior in Awake Rats" @default.
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- W3081471898 doi "https://doi.org/10.1093/cercor/bhaa227" @default.
- W3081471898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7727348" @default.
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- W3081471898 hasPublicationYear "2020" @default.
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