FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081529512> ?p ?o ?g. }

• W3081529512 abstract "Abstract Mesenchymal stem cells (MSCs) driven gene-directed enzyme prodrug therapy has emerged as a potential strategy for cancer treatment. The tumour-nesting properties of MSCs enable these vehicles to target tumours and metastases with effective therapies. A crucial step in engineering MSCs is the delivery of genetic material with low toxicity and high efficiency. Due to the low efficiency of current transfection methods, viral vectors are used widely to modify MSCs in preclinical and clinical studies. We show, for the first time, the high transfection efficiency (> 80%) of human adipose tissue derived-MSCs (AT-MSCs) using a cost-effective and off-the-shelf Polyethylenimine, in the presence of histone deacetylase 6 inhibitor and fusogenic lipids. Notably, the phenotypes of MSCs remained unchanged post-modification. AT-MSCs engineered with a fused transgene, yeast cytosine deaminase::uracil phosphoribosyltransferase (CDy::UPRT) displayed potent cytotoxic effects against breast, glioma, gastric cancer cells in vitro. The efficiency of eliminating gastric cell lines were effective even when using 7-day post-transfected AT-MSCs, indicative of the sustained expression and function of the therapeutic gene. In addition, significant inhibition of temozolomide resistant glioma tumour growth in vivo was observed with a single dose of therapeutic MSC. This study demonstrated an efficient non-viral modification process for MSC-based prodrug therapy." @default.
• W3081529512 created "2020-09-08" @default.
• W3081529512 creator A5013483856 @default.
• W3081529512 creator A5021801679 @default.
• W3081529512 creator A5024482611 @default.
• W3081529512 creator A5073293461 @default.
• W3081529512 creator A5091463181 @default.
• W3081529512 date "2020-08-31" @default.
• W3081529512 modified "2023-09-23" @default.
• W3081529512 title "A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy" @default.
• W3081529512 cites W1509161728 @default.
• W3081529512 cites W1862365802 @default.
• W3081529512 cites W1966774802 @default.
• W3081529512 cites W1976780000 @default.
• W3081529512 cites W1987944180 @default.
• W3081529512 cites W1993252085 @default.
• W3081529512 cites W2000647702 @default.
• W3081529512 cites W2005329583 @default.
• W3081529512 cites W2007831086 @default.
• W3081529512 cites W2008510535 @default.
• W3081529512 cites W2014356856 @default.
• W3081529512 cites W2015569086 @default.
• W3081529512 cites W2025371271 @default.
• W3081529512 cites W2033219939 @default.
• W3081529512 cites W2046143832 @default.
• W3081529512 cites W2055702291 @default.
• W3081529512 cites W2057723082 @default.
• W3081529512 cites W2073063509 @default.
• W3081529512 cites W2073549817 @default.
• W3081529512 cites W2074762435 @default.
• W3081529512 cites W2076704745 @default.
• W3081529512 cites W2078025169 @default.
• W3081529512 cites W2093172278 @default.
• W3081529512 cites W209377287 @default.
• W3081529512 cites W2096338956 @default.
• W3081529512 cites W2099564459 @default.
• W3081529512 cites W2115798437 @default.
• W3081529512 cites W2119362862 @default.
• W3081529512 cites W2124885975 @default.
• W3081529512 cites W2129920271 @default.
• W3081529512 cites W2130607894 @default.
• W3081529512 cites W2140689214 @default.
• W3081529512 cites W2141815918 @default.
• W3081529512 cites W2145163108 @default.
• W3081529512 cites W2161607902 @default.
• W3081529512 cites W2171791800 @default.
• W3081529512 cites W2220427438 @default.
• W3081529512 cites W2301051006 @default.
• W3081529512 cites W2336044299 @default.
• W3081529512 cites W2346999680 @default.
• W3081529512 cites W2408571709 @default.
• W3081529512 cites W2414238845 @default.
• W3081529512 cites W2464579909 @default.
• W3081529512 cites W2558647619 @default.
• W3081529512 cites W2561872017 @default.
• W3081529512 cites W2734638653 @default.
• W3081529512 cites W2769263776 @default.
• W3081529512 cites W2769795302 @default.
• W3081529512 cites W2771830523 @default.
• W3081529512 cites W2790571094 @default.
• W3081529512 cites W2805892376 @default.
• W3081529512 cites W2889441451 @default.
• W3081529512 cites W2899807078 @default.
• W3081529512 cites W2904058752 @default.
• W3081529512 cites W2905794952 @default.
• W3081529512 cites W2914785669 @default.
• W3081529512 cites W2915238668 @default.
• W3081529512 cites W2915975767 @default.
• W3081529512 cites W2924629148 @default.
• W3081529512 cites W2937431312 @default.
• W3081529512 cites W2943031177 @default.
• W3081529512 cites W2963623336 @default.
• W3081529512 cites W2991416247 @default.
• W3081529512 cites W2992079273 @default.
• W3081529512 cites W63612215 @default.
• W3081529512 doi "https://doi.org/10.1038/s41598-020-71224-2" @default.
• W3081529512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7458920" @default.
• W3081529512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32868813" @default.
• W3081529512 hasPublicationYear "2020" @default.
• W3081529512 type Work @default.
• W3081529512 sameAs 3081529512 @default.
• W3081529512 citedByCount "14" @default.
• W3081529512 countsByYear W30815295122021 @default.
• W3081529512 countsByYear W30815295122022 @default.
• W3081529512 countsByYear W30815295122023 @default.
• W3081529512 crossrefType "journal-article" @default.
• W3081529512 hasAuthorship W3081529512A5013483856 @default.
• W3081529512 hasAuthorship W3081529512A5021801679 @default.
• W3081529512 hasAuthorship W3081529512A5024482611 @default.
• W3081529512 hasAuthorship W3081529512A5073293461 @default.
• W3081529512 hasAuthorship W3081529512A5091463181 @default.
• W3081529512 hasBestOaLocation W30815295121 @default.
• W3081529512 hasConcept C104317684 @default.
• W3081529512 hasConcept C108215921 @default.
• W3081529512 hasConcept C111599444 @default.
• W3081529512 hasConcept C135983454 @default.
• W3081529512 hasConcept C185592680 @default.
• W3081529512 hasConcept C198826908 @default.
• W3081529512 hasConcept C2777748644 @default.
• W3081529512 hasConcept C502942594 @default.

• next