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- W3081561647 abstract "Down syndrome (DS) is one of the most common chromosomal abnormalities, which is associated with various unique physicaltraits and developmental delay. As the mortality rate of people with DS has declined, life expectancy at birth of people with DS wasincreased between recent 50 years. Life expectancy for the time period of 1953 to 2000 was 58.6 year, compared with 16.2 years forthe period of 1948 to 1957 among those registered in a DS database in Western Australia. In Japan, the life expectancy for 1,052 DSwho were born between 1966 and 1975 increased to 48.9 years. In Western Australia, in contrast to female longevity in the generalpopulation, males with DS were found to have significantly longer life expectancies, compared with their female counterparts. Weinvestigated sex differences in congenital heart disease (CHD), which may be related to mortality using data on 1310 people with DS(626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people withDS. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females(199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018). Higher prevalence and greater severity of CHD in femalesmay contribute to poor prognoses. We found that the most common cardiac anomalies (main lesions) were VSD, ASD, AVSD, PDAand TOF, which together accounted for 95.5% of all CHD cases. Among people with DS born before 1979, in the1980s or 1990s,we found that significantly more female than male subjects had CHD, but we found no significant sex difference for subjects bornin 2000 or later. Many factors seem to have contributed to this change, including the improvement of diagnostic techniques, such asechocardiographic examination, and improvements in heart surgery. This shift may be attributed to a great increase in the diagnosisof less severe CHD for both sexes. Improvements in quality of life of individuals with DS have resulted from prognosis in medicalcare, identification and treatment of CHD in perinatal and postnatal period." @default.
- W3081561647 created "2020-09-08" @default.
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- W3081561647 date "2020-01-01" @default.
- W3081561647 modified "2023-09-28" @default.
- W3081561647 title "Sex differences in congenital heart disease in Japanese Down Syndrome" @default.
- W3081561647 hasPublicationYear "2020" @default.
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