Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081567884> ?p ?o ?g. }
- W3081567884 endingPage "6390" @default.
- W3081567884 startingPage "6390" @default.
- W3081567884 abstract "Sirtuins have become important players in renal damage in hypertension and diabetes, but their value as biomarkers is poorly assessed. The aims of the study were to evaluate the levels of sirtuin1 (SIRT1), and two miRNAs that regulate SIRT1 expression in hypertensive patients with incipient renal damage with and without diabetes. We quantified urinary SIRT1 and claudin 1 (CLDN1) mRNA and miR34-a and miR-200a levels by quantitative real-time polymerase chain reaction (RT-qPCR) from patients and in cultured podocytes treated with high glucose and angiotensin II. Western blot and fluorescence analyses were also performed. We found decreased SIRT1 levels in patients with increased urinary albumin excretion (UAE), the lowest with diabetes presence, and a strong association with UAE, discriminating incipient renal damage. In vitro experiments also showed SIRT1 overall decreases in podocyte cultures under treatment conditions. In urine samples, miR-34a was reduced and miR-200a increased, both related to UAE levels. However, both miRNAs were generally increased in podocyte cultures under high glucose and angiotensin-II treatment. These results show a significant urinary SIRT1 decrease in albuminuric hypertensive patients, strongly associated with albuminuria, suggesting that SIRT1 could be a potential and non-invasive method to assess incipient renal damage in hypertensive patients." @default.
- W3081567884 created "2020-09-08" @default.
- W3081567884 creator A5007735183 @default.
- W3081567884 creator A5013131609 @default.
- W3081567884 creator A5014327365 @default.
- W3081567884 creator A5035823924 @default.
- W3081567884 creator A5044716437 @default.
- W3081567884 creator A5064417836 @default.
- W3081567884 creator A5068591576 @default.
- W3081567884 date "2020-09-02" @default.
- W3081567884 modified "2023-09-24" @default.
- W3081567884 title "Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension" @default.
- W3081567884 cites W1983760122 @default.
- W3081567884 cites W1994706382 @default.
- W3081567884 cites W2011409573 @default.
- W3081567884 cites W2040580133 @default.
- W3081567884 cites W2046385403 @default.
- W3081567884 cites W2049230993 @default.
- W3081567884 cites W2059843925 @default.
- W3081567884 cites W2075863664 @default.
- W3081567884 cites W2079506738 @default.
- W3081567884 cites W2092244061 @default.
- W3081567884 cites W2099760082 @default.
- W3081567884 cites W2105631023 @default.
- W3081567884 cites W2118964113 @default.
- W3081567884 cites W2134211155 @default.
- W3081567884 cites W2142873303 @default.
- W3081567884 cites W2147258717 @default.
- W3081567884 cites W2157799833 @default.
- W3081567884 cites W2158423414 @default.
- W3081567884 cites W2159277297 @default.
- W3081567884 cites W2168287443 @default.
- W3081567884 cites W2168450345 @default.
- W3081567884 cites W2185616741 @default.
- W3081567884 cites W2301340697 @default.
- W3081567884 cites W2303848959 @default.
- W3081567884 cites W2346461079 @default.
- W3081567884 cites W2400520418 @default.
- W3081567884 cites W2468813696 @default.
- W3081567884 cites W2552436855 @default.
- W3081567884 cites W2552554514 @default.
- W3081567884 cites W2563503838 @default.
- W3081567884 cites W2585502450 @default.
- W3081567884 cites W2606888265 @default.
- W3081567884 cites W2757984372 @default.
- W3081567884 cites W2785375334 @default.
- W3081567884 cites W2788823940 @default.
- W3081567884 cites W2793697099 @default.
- W3081567884 cites W2800110090 @default.
- W3081567884 cites W2802947784 @default.
- W3081567884 cites W2804304807 @default.
- W3081567884 cites W2888589263 @default.
- W3081567884 cites W2894569443 @default.
- W3081567884 cites W2912619855 @default.
- W3081567884 cites W2912698023 @default.
- W3081567884 cites W2913166170 @default.
- W3081567884 cites W2920816866 @default.
- W3081567884 cites W2920932117 @default.
- W3081567884 cites W2946012339 @default.
- W3081567884 cites W2948586380 @default.
- W3081567884 cites W2978493967 @default.
- W3081567884 cites W2989832464 @default.
- W3081567884 cites W3007313106 @default.
- W3081567884 cites W3011766212 @default.
- W3081567884 cites W3012694474 @default.
- W3081567884 cites W3028677469 @default.
- W3081567884 cites W3036634150 @default.
- W3081567884 cites W4214826712 @default.
- W3081567884 cites W4292528167 @default.
- W3081567884 doi "https://doi.org/10.3390/ijms21176390" @default.
- W3081567884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7503821" @default.
- W3081567884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32887498" @default.
- W3081567884 hasPublicationYear "2020" @default.
- W3081567884 type Work @default.
- W3081567884 sameAs 3081567884 @default.
- W3081567884 citedByCount "9" @default.
- W3081567884 countsByYear W30815678842021 @default.
- W3081567884 countsByYear W30815678842022 @default.
- W3081567884 countsByYear W30815678842023 @default.
- W3081567884 crossrefType "journal-article" @default.
- W3081567884 hasAuthorship W3081567884A5007735183 @default.
- W3081567884 hasAuthorship W3081567884A5013131609 @default.
- W3081567884 hasAuthorship W3081567884A5014327365 @default.
- W3081567884 hasAuthorship W3081567884A5035823924 @default.
- W3081567884 hasAuthorship W3081567884A5044716437 @default.
- W3081567884 hasAuthorship W3081567884A5064417836 @default.
- W3081567884 hasAuthorship W3081567884A5068591576 @default.
- W3081567884 hasBestOaLocation W30815678841 @default.
- W3081567884 hasConcept C104317684 @default.
- W3081567884 hasConcept C126322002 @default.
- W3081567884 hasConcept C126894567 @default.
- W3081567884 hasConcept C134018914 @default.
- W3081567884 hasConcept C2776174234 @default.
- W3081567884 hasConcept C2777146197 @default.
- W3081567884 hasConcept C2779561371 @default.
- W3081567884 hasConcept C2780026642 @default.
- W3081567884 hasConcept C2780091579 @default.
- W3081567884 hasConcept C2781197716 @default.