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- W3081569894 endingPage "1934578X2095364" @default.
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- W3081569894 abstract "During the coronavirus disease 2019 (COVID-19) pandemic, numerous existing chemicals have been screened for antiviral potential against the emerging coronavirus severe acute respiratory syndrome coronavirus 2. Chloroquine and hydroxychloroquine, after exhibiting potent in vitro efficacy, have gained tremendous attention. Both therapeutics are derivatives of natural alkaloid quinine and were first synthesized to treat malaria. Thereafter, the pharmaceutical applications of the agents have expanded to many new areas. In this article, the medicinal history and pharmacological activities of chloroquine and hydroxychloroquine are summarized. Antimalarial, anti-inflammatory, antitumor, antiviral properties, and therapeutic potential in the emerging viral infection COVID-19 are discussed. Pharmacokinetics, adverse effects, and toxicities are reviewed." @default.
- W3081569894 created "2020-09-08" @default.
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- W3081569894 date "2020-09-01" @default.
- W3081569894 modified "2023-09-27" @default.
- W3081569894 title "Pharmacological Advances of Chloroquine and Hydroxychloroquine: From Antimalarials to Investigative Therapies in COVID-19" @default.
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- W3081569894 doi "https://doi.org/10.1177/1934578x20953648" @default.
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