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• W3081586810 endingPage "325" @default.
• W3081586810 startingPage "310" @default.
• W3081586810 abstract "Astrocyte heterogeneity is an emerging concept in which astrocytes within or between brain regions show variable morphological and/or gene expression profiles that presumably reflect different functional roles. Recent evidence indicates that retrotrapezoid nucleus (RTN) astrocytes sense changes in tissue CO2/ H+ to regulate respiratory activity; however, mechanism(s) by which they do so remain unclear. Alterations in inward K+ currents represent a potential mechanism by which CO2 /H+ signals may be conveyed to neurons. Here, we use slice electrophysiology in rats of either sex to show that RTN astrocytes intrinsically respond to CO2 /H+ by inhibition of an inward rectifying potassium (Kir ) conductance and depolarization of the membrane, while cortical astrocytes do not exhibit such CO2 /H+ -sensitive properties. Application of Ba2+ mimics the effect of CO2 /H+ on RTN astrocytes as measured by reductions in astrocyte Kir -like currents and increased RTN neuronal firing. These CO2 /H+ -sensitive currents increase developmentally, in parallel to an increased expression in Kir 4.1 and Kir 5.1 in the brainstem. Finally, the involvement of Kir 5.1 in the CO2 /H+ -sensitive current was verified using a Kir5.1 KO rat. These data suggest that Kir inhibition by CO2 /H+ may govern the degree to which astrocytes mediate downstream chemoreceptive signaling events through cell-autonomous mechanisms. These results identify Kir channels as potentially important regional CO2 /H+ sensors early in development, thus expanding our understanding of how astrocyte heterogeneity may uniquely support specific neural circuits and behaviors." @default.
• W3081586810 created "2020-09-08" @default.
• W3081586810 creator A5005174825 @default.
• W3081586810 creator A5016747509 @default.
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• W3081586810 creator A5034525449 @default.
• W3081586810 creator A5071337074 @default.
• W3081586810 creator A5090802965 @default.
• W3081586810 date "2020-08-31" @default.
• W3081586810 modified "2023-10-14" @default.
• W3081586810 title "K _ir 5. <scp> 1‐dependent CO ₂ </scp> /H ⁺ ‐sensitive currents contribute to astrocyte heterogeneity across brain regions" @default.
• W3081586810 cites W1493974636 @default.
• W3081586810 cites W1539460880 @default.
• W3081586810 cites W163544632 @default.
• W3081586810 cites W1641010217 @default.
• W3081586810 cites W1786188576 @default.
• W3081586810 cites W1940376800 @default.
• W3081586810 cites W1974045578 @default.
• W3081586810 cites W1974801807 @default.
• W3081586810 cites W1975372045 @default.
• W3081586810 cites W1981627824 @default.
• W3081586810 cites W1981893433 @default.
• W3081586810 cites W1983210704 @default.
• W3081586810 cites W1985950684 @default.
• W3081586810 cites W1995579155 @default.
• W3081586810 cites W2005065238 @default.
• W3081586810 cites W2007814938 @default.
• W3081586810 cites W2007957058 @default.
• W3081586810 cites W2012034410 @default.
• W3081586810 cites W2023105628 @default.
• W3081586810 cites W2032154466 @default.
• W3081586810 cites W2032681138 @default.
• W3081586810 cites W2041273214 @default.
• W3081586810 cites W2043661303 @default.
• W3081586810 cites W2043776403 @default.
• W3081586810 cites W2047106071 @default.
• W3081586810 cites W2047323883 @default.
• W3081586810 cites W2047594016 @default.
• W3081586810 cites W2047806620 @default.
• W3081586810 cites W2050382124 @default.
• W3081586810 cites W2050405161 @default.
• W3081586810 cites W2054275187 @default.
• W3081586810 cites W2055129010 @default.
• W3081586810 cites W2059018982 @default.
• W3081586810 cites W2064574624 @default.
• W3081586810 cites W2071032039 @default.
• W3081586810 cites W2071269898 @default.
• W3081586810 cites W2083971880 @default.
• W3081586810 cites W2088574511 @default.
• W3081586810 cites W2092134954 @default.
• W3081586810 cites W2093976723 @default.
• W3081586810 cites W2099365009 @default.
• W3081586810 cites W2103279601 @default.
• W3081586810 cites W2107322719 @default.
• W3081586810 cites W2117572051 @default.
• W3081586810 cites W2118661818 @default.
• W3081586810 cites W2126221029 @default.
• W3081586810 cites W2129082075 @default.
• W3081586810 cites W2131610419 @default.
• W3081586810 cites W2135730315 @default.
• W3081586810 cites W2136077454 @default.
• W3081586810 cites W2138263789 @default.
• W3081586810 cites W2138427761 @default.
• W3081586810 cites W2141019919 @default.
• W3081586810 cites W2141136135 @default.
• W3081586810 cites W2145202762 @default.
• W3081586810 cites W2145242126 @default.
• W3081586810 cites W2149658732 @default.
• W3081586810 cites W2156790391 @default.
• W3081586810 cites W2157170162 @default.
• W3081586810 cites W2161227647 @default.
• W3081586810 cites W2162338856 @default.
• W3081586810 cites W2163334026 @default.
• W3081586810 cites W2163695755 @default.
• W3081586810 cites W2169554891 @default.
• W3081586810 cites W2179096324 @default.
• W3081586810 cites W2185055342 @default.
• W3081586810 cites W2278495047 @default.
• W3081586810 cites W2301368457 @default.
• W3081586810 cites W2304292493 @default.
• W3081586810 cites W2312098387 @default.
• W3081586810 cites W2318926611 @default.
• W3081586810 cites W2342085519 @default.
• W3081586810 cites W2541018049 @default.
• W3081586810 cites W2559702793 @default.
• W3081586810 cites W2562984037 @default.
• W3081586810 cites W2730762223 @default.
• W3081586810 cites W2735769265 @default.
• W3081586810 cites W2744386347 @default.
• W3081586810 cites W2755218443 @default.
• W3081586810 cites W2760574659 @default.
• W3081586810 cites W2765768583 @default.
• W3081586810 cites W2777525962 @default.
• W3081586810 cites W2787343838 @default.
• W3081586810 cites W2791726934 @default.
• W3081586810 cites W2799384061 @default.
• W3081586810 cites W2802994942 @default.

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