Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081605327> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3081605327 startingPage "7" @default.
- W3081605327 abstract "Croton macrostachyus has been used in traditional medicine to manage heart failure and other heart diseases in Ethiopia.To evaluate in vitro antioxidant and in vivo cardioprotective activities of stem bark extract and solvent fractions of Crotonmacrostachyus on cyclophosphamide induced cardiotoxicity in rats.The antioxidant activities of crude extract and solvent fractions of Crotonmacrostachyus were evaluated by using DPPH radical scavenging assay method. Whereas, cardioprotective activity, the negative control group were treated with cyclophosphamide alone (200 mg/kg, i.p.). Enalapril 10 mg/kg was used as a reference drug. The crude extracts were administered at three dose levels (100, 200, and 400 mg/kg). Aqueous and ethyl acetate fractions were given at two dose levels (100 and 200 mg/kg). Excepting normal control group, all groups were subjected to cyclophosphamide toxicity on the first day. The cardioprotective activity were evaluated by using body weight, heart weight and serum cardiac biomarkers. Also, histopathological studies of heart tissues were carried out.The results of antioxidant studies reveal that the crude extract and solvent fractions exhibited free radical scavenging activity in a dose dependent manner. Serum cardiac biomarkers were decreased significantly by the administration of crude extracts and solvent fractions. Histopathological results of heart also supported the cardioprotective activity of the crude extract and solvent fractions of Croton macrostachyus.The results of the present study indicate that the crude extract and solvent fractions of Croton macrostachyus possesses antioxidant and cardioprotective activities." @default.
- W3081605327 created "2020-09-08" @default.
- W3081605327 creator A5080950348 @default.
- W3081605327 date "2020-01-01" @default.
- W3081605327 modified "2023-09-23" @default.
- W3081605327 title "Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide-Induced Cardiotoxicity in Rats" @default.
- W3081605327 hasPublicationYear "2020" @default.
- W3081605327 type Work @default.
- W3081605327 sameAs 3081605327 @default.
- W3081605327 citedByCount "0" @default.
- W3081605327 crossrefType "journal-article" @default.
- W3081605327 hasAuthorship W3081605327A5080950348 @default.
- W3081605327 hasConcept C150903083 @default.
- W3081605327 hasConcept C178790620 @default.
- W3081605327 hasConcept C185592680 @default.
- W3081605327 hasConcept C207001950 @default.
- W3081605327 hasConcept C2778004101 @default.
- W3081605327 hasConcept C2778233292 @default.
- W3081605327 hasConcept C2779858419 @default.
- W3081605327 hasConcept C2780471494 @default.
- W3081605327 hasConcept C2781401929 @default.
- W3081605327 hasConcept C29730261 @default.
- W3081605327 hasConcept C55493867 @default.
- W3081605327 hasConcept C556039675 @default.
- W3081605327 hasConcept C71924100 @default.
- W3081605327 hasConcept C86803240 @default.
- W3081605327 hasConcept C98274493 @default.
- W3081605327 hasConceptScore W3081605327C150903083 @default.
- W3081605327 hasConceptScore W3081605327C178790620 @default.
- W3081605327 hasConceptScore W3081605327C185592680 @default.
- W3081605327 hasConceptScore W3081605327C207001950 @default.
- W3081605327 hasConceptScore W3081605327C2778004101 @default.
- W3081605327 hasConceptScore W3081605327C2778233292 @default.
- W3081605327 hasConceptScore W3081605327C2779858419 @default.
- W3081605327 hasConceptScore W3081605327C2780471494 @default.
- W3081605327 hasConceptScore W3081605327C2781401929 @default.
- W3081605327 hasConceptScore W3081605327C29730261 @default.
- W3081605327 hasConceptScore W3081605327C55493867 @default.
- W3081605327 hasConceptScore W3081605327C556039675 @default.
- W3081605327 hasConceptScore W3081605327C71924100 @default.
- W3081605327 hasConceptScore W3081605327C86803240 @default.
- W3081605327 hasConceptScore W3081605327C98274493 @default.
- W3081605327 hasIssue "4" @default.
- W3081605327 hasLocation W30816053271 @default.
- W3081605327 hasOpenAccess W3081605327 @default.
- W3081605327 hasPrimaryLocation W30816053271 @default.
- W3081605327 hasRelatedWork W1983562075 @default.
- W3081605327 hasRelatedWork W2022852559 @default.
- W3081605327 hasRelatedWork W2036386221 @default.
- W3081605327 hasRelatedWork W2136843691 @default.
- W3081605327 hasRelatedWork W2136858096 @default.
- W3081605327 hasRelatedWork W2150275902 @default.
- W3081605327 hasRelatedWork W2170045609 @default.
- W3081605327 hasRelatedWork W2189616371 @default.
- W3081605327 hasRelatedWork W2318550249 @default.
- W3081605327 hasRelatedWork W2771130227 @default.
- W3081605327 hasRelatedWork W2922536661 @default.
- W3081605327 hasRelatedWork W3033074866 @default.
- W3081605327 hasRelatedWork W3035050355 @default.
- W3081605327 hasRelatedWork W3081225915 @default.
- W3081605327 hasRelatedWork W3129249637 @default.
- W3081605327 hasRelatedWork W3132160249 @default.
- W3081605327 hasRelatedWork W89402261 @default.
- W3081605327 hasRelatedWork W2185210568 @default.
- W3081605327 hasRelatedWork W2185777638 @default.
- W3081605327 hasRelatedWork W3136263454 @default.
- W3081605327 hasVolume "16" @default.
- W3081605327 isParatext "false" @default.
- W3081605327 isRetracted "false" @default.
- W3081605327 magId "3081605327" @default.
- W3081605327 workType "article" @default.