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- W3081615404 abstract "TcpP homologs are widespread throughout the Vibrio genus; however, the only protein in this family described thus far is a V. cholerae virulence regulator. Here, we show that HbtR, the TcpP homolog in V. fischeri , has both a biological role and regulatory pathway completely unlike those in V. cholerae . Through its repression of the quorum-signaling regulator LitR, HbtR affects the expression of genes important for colonization of the E. scolopes light organ. While LitR becomes activated within the crypts and upregulates luminescence and exopolysaccharide genes and downregulates chemotaxis and motility genes, it appears that HbtR, upon expulsion of V. fischeri cells into seawater, reverses this process to aid the switch from a symbiotic to a planktonic state. The possible importance of HbtR to the survival of V. fischeri outside its animal host may have broader implications for the ways in which bacteria transition between often vastly different environmental niches." @default.
- W3081615404 created "2020-09-08" @default.
- W3081615404 creator A5030540458 @default.
- W3081615404 creator A5044418793 @default.
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- W3081615404 date "2020-10-27" @default.
- W3081615404 modified "2023-10-16" @default.
- W3081615404 title "HbtR, a Heterofunctional Homolog of the Virulence Regulator TcpP, Facilitates the Transition between Symbiotic and Planktonic Lifestyles in Vibrio fischeri" @default.
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- W3081615404 doi "https://doi.org/10.1128/mbio.01624-20" @default.
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