Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081617992> ?p ?o ?g. }
- W3081617992 abstract "Abstract CD4 T cell is crucial in CMV infection, but its role is still unclear during this process. Here, we present a single-cell RNA-seq together with T cell receptor (TCR) sequencing to screen the heterogenicity and potential function of CMV pp65 reactivated CD4+ T cell subsets from human peripheral blood, and unveil their potential interactions. Notably, Treg composed the major part of these reactivated cells. Treg gene expression data revealed multiple transcripts of both inflammatory and inhibitory functions. Additionally, we describe the detailed phenotypes of CMV-reactivated effector-memory (Tem), cytotoxic T (CTL), and naïve T cells at the single-cell resolution, and implied the direct derivation of CTL from naïve CD4+ T cells. By analyzing the TCR repertoire, we identified a clonality in stimulated Tem and CTLs, and a tight relationship of Tem and CTL showing a large share in TCR. This study provides clues for understanding the function of CD4+ T cells subsets and unveils their interaction in CMV infection, and may promote the development of CMV immunotherapy." @default.
- W3081617992 created "2020-09-08" @default.
- W3081617992 creator A5003607770 @default.
- W3081617992 creator A5024126340 @default.
- W3081617992 creator A5029695887 @default.
- W3081617992 creator A5044820391 @default.
- W3081617992 creator A5051449882 @default.
- W3081617992 creator A5074034944 @default.
- W3081617992 date "2020-08-31" @default.
- W3081617992 modified "2023-10-16" @default.
- W3081617992 title "Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencing" @default.
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