FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081620530> ?p ?o ?g. }

• W3081620530 endingPage "72" @default.
• W3081620530 startingPage "1" @default.
• W3081620530 abstract "The discovery and development of new medicines classically involves a linear process of basic biomedical research to uncover potential targets for drug action, followed by applied, or translational, research to identify candidate products and establish their effectiveness and safety. This Working Paper describes the public sector contribution to that process by tracing funding from the National Institutes of Health (NIH) related to published research on each of the 356 new drugs approved by the U.S. Food and Drug Administration from 2010-2019 as well as research on their 219 biological targets. Specifically, we describe the timelines of clinical development for these products and proxy measures of their importance, including designations as first-in- class or expedited approvals. We model the maturation of basic research on the biological targets to determine the initiation and established points of this research and demonstrate that none of these products were approved before this enabling research passed the established point. This body of essential research comprised 2 million publications, of which 424 thousand were supported by 515 thousand Funding Years of NIH Project support totaling $195 billion. Research on the 356 drugs comprised 244 thousand publications, of which 39 thousand were supported by 64 thousand Funding Years of NIH Project support totaling $36 billion. Overall, NIH funding contributed to research associated with every new drug approved from 2010-2019, totaling $230 billion. This funding supported investigator-initiated Research Projects, Cooperative Agreements for government-led research on topics of particular importance, as well as Research Program Projects and Centers and training to support the research infrastructure. This NIH funding also produced 22 thousand patents, which provided marketing exclusivity for 27 (8.6%) of the drugs approved 2010-2019. These data demonstrate the essential role of public sector-funded basic research in drug discovery and development, as well as the scale and character of this funding. It also demonstrates the limited mechanisms available for recognizing the value created by these early investments and ensuring appropriate public returns. This analysis demonstrates the importance of sustained public investment in basic biomedical science as well as the need for policy innovations that fully realize the value of public sector investments in pharmaceutical innovation that ensure that these investments yield meaningful improvements in health." @default.
• W3081620530 created "2020-09-08" @default.
• W3081620530 creator A5005781523 @default.
• W3081620530 creator A5073771472 @default.
• W3081620530 creator A5084575471 @default.
• W3081620530 date "2020-09-01" @default.
• W3081620530 modified "2023-09-26" @default.
• W3081620530 title "Government as the First Investor in Biopharmaceutical Innovation: Evidence From New Drug Approvals 2010–2019" @default.
• W3081620530 cites W1052047734 @default.
• W3081620530 cites W1161847421 @default.
• W3081620530 cites W131196319 @default.
• W3081620530 cites W1500723452 @default.
• W3081620530 cites W1539433677 @default.
• W3081620530 cites W1966572897 @default.
• W3081620530 cites W1975727427 @default.
• W3081620530 cites W1976283928 @default.
• W3081620530 cites W1979469090 @default.
• W3081620530 cites W1980985444 @default.
• W3081620530 cites W1980996290 @default.
• W3081620530 cites W1986799651 @default.
• W3081620530 cites W1990484467 @default.
• W3081620530 cites W2006270274 @default.
• W3081620530 cites W2008573694 @default.
• W3081620530 cites W2019538919 @default.
• W3081620530 cites W2023158775 @default.
• W3081620530 cites W2028279608 @default.
• W3081620530 cites W2028959846 @default.
• W3081620530 cites W2029774593 @default.
• W3081620530 cites W2031381407 @default.
• W3081620530 cites W2032035931 @default.
• W3081620530 cites W2035496725 @default.
• W3081620530 cites W2046088696 @default.
• W3081620530 cites W2057416589 @default.
• W3081620530 cites W2058781281 @default.
• W3081620530 cites W2060333462 @default.
• W3081620530 cites W2062092016 @default.
• W3081620530 cites W2067639844 @default.
• W3081620530 cites W2068373516 @default.
• W3081620530 cites W2070036100 @default.
• W3081620530 cites W2075792487 @default.
• W3081620530 cites W2076256706 @default.
• W3081620530 cites W2076409971 @default.
• W3081620530 cites W2083258699 @default.
• W3081620530 cites W2084073221 @default.
• W3081620530 cites W2085043513 @default.
• W3081620530 cites W2086147520 @default.
• W3081620530 cites W2087280362 @default.
• W3081620530 cites W2090672746 @default.
• W3081620530 cites W2091750100 @default.
• W3081620530 cites W2097833714 @default.
• W3081620530 cites W2099877908 @default.
• W3081620530 cites W2103097484 @default.
• W3081620530 cites W2104494483 @default.
• W3081620530 cites W2109314733 @default.
• W3081620530 cites W2113928234 @default.
• W3081620530 cites W2119924558 @default.
• W3081620530 cites W2121175754 @default.
• W3081620530 cites W2121280379 @default.
• W3081620530 cites W2128802209 @default.
• W3081620530 cites W2147649479 @default.
• W3081620530 cites W2150075917 @default.
• W3081620530 cites W2156779720 @default.
• W3081620530 cites W2159486278 @default.
• W3081620530 cites W2170379760 @default.
• W3081620530 cites W2182364433 @default.
• W3081620530 cites W2273267066 @default.
• W3081620530 cites W2310501546 @default.
• W3081620530 cites W2330331754 @default.
• W3081620530 cites W2389472352 @default.
• W3081620530 cites W2398134517 @default.
• W3081620530 cites W2410439081 @default.
• W3081620530 cites W2419333550 @default.
• W3081620530 cites W2476597428 @default.
• W3081620530 cites W2481749265 @default.
• W3081620530 cites W2513403311 @default.
• W3081620530 cites W2520858522 @default.
• W3081620530 cites W2586190916 @default.
• W3081620530 cites W2586827268 @default.
• W3081620530 cites W2591466541 @default.
• W3081620530 cites W2597693078 @default.
• W3081620530 cites W2602877728 @default.
• W3081620530 cites W2612115802 @default.
• W3081620530 cites W2686044652 @default.
• W3081620530 cites W2729684734 @default.
• W3081620530 cites W2743884731 @default.
• W3081620530 cites W2746717271 @default.
• W3081620530 cites W2750636690 @default.
• W3081620530 cites W2754138884 @default.
• W3081620530 cites W2757281165 @default.
• W3081620530 cites W2765472674 @default.
• W3081620530 cites W2769173154 @default.
• W3081620530 cites W2773935049 @default.
• W3081620530 cites W2789816271 @default.
• W3081620530 cites W2791975964 @default.
• W3081620530 cites W2793539832 @default.
• W3081620530 cites W2807263029 @default.
• W3081620530 cites W2889736748 @default.
• W3081620530 cites W2909860262 @default.

• next