Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081629905> ?p ?o ?g. }
- W3081629905 abstract "Abstract Objective Perfluorooctanoic acid (PFOA) is a ubiquitous environmental contaminant and a known immune suppressant in humans and experimental animal models. Studies on PFOA have focused on suppression of the adaptive immune response; however, little is known of the impact on innate immunity, especially during embryogenesis. Therefore, we utilized the zebrafish chemotaxis assay coupled with in situ hybridization for myeloperoxidase expression to determine the effects of PFOA exposure on neutrophil migration in the developing zebrafish embryo. Zebrafish embryos are a well-established in vivo model that exhibit high homology with the development of human innate immunity. Results Treatment of zebrafish with increasing concentrations of PFOA identified the lethal concentration in 50% of the embryos (LC 50 ) to be 300 mg/L. Utilizing the zebrafish chemotaxis assay, this study showed that wounding induced significant neutrophil migration to the site of injury, and that neutrophil number in the wound region was significantly reduced in response to 48-h PFOA exposure (well below doses causing acute mortality). This study demonstrates that the developing embryo is sensitive to PFOA exposure and that PFOA can modify the innate immune system during embryonic development. These results lay the groundwork for future investigation on the mechanisms underlying PFOA-induced developmental immunotoxicity." @default.
- W3081629905 created "2020-09-08" @default.
- W3081629905 creator A5019737130 @default.
- W3081629905 creator A5039152252 @default.
- W3081629905 creator A5041084992 @default.
- W3081629905 creator A5065015794 @default.
- W3081629905 creator A5087956049 @default.
- W3081629905 date "2020-08-31" @default.
- W3081629905 modified "2023-10-14" @default.
- W3081629905 title "Exposure to perfluorooctanoic acid (PFOA) decreases neutrophil migration response to injury in zebrafish embryos" @default.
- W3081629905 cites W1506830997 @default.
- W3081629905 cites W1969235613 @default.
- W3081629905 cites W197715220 @default.
- W3081629905 cites W1983832105 @default.
- W3081629905 cites W1986194759 @default.
- W3081629905 cites W1986258895 @default.
- W3081629905 cites W2031220427 @default.
- W3081629905 cites W2040558296 @default.
- W3081629905 cites W2043748391 @default.
- W3081629905 cites W2044046770 @default.
- W3081629905 cites W2064994678 @default.
- W3081629905 cites W2079744842 @default.
- W3081629905 cites W2099548299 @default.
- W3081629905 cites W2103692242 @default.
- W3081629905 cites W2104856748 @default.
- W3081629905 cites W2126914041 @default.
- W3081629905 cites W2140367720 @default.
- W3081629905 cites W2148333750 @default.
- W3081629905 cites W2228240411 @default.
- W3081629905 cites W2419571985 @default.
- W3081629905 cites W2533524005 @default.
- W3081629905 cites W2592331100 @default.
- W3081629905 cites W2609061311 @default.
- W3081629905 cites W2613600925 @default.
- W3081629905 cites W2761133614 @default.
- W3081629905 cites W2766235461 @default.
- W3081629905 cites W2903188676 @default.
- W3081629905 cites W3013111721 @default.
- W3081629905 cites W4248636029 @default.
- W3081629905 doi "https://doi.org/10.1186/s13104-020-05255-3" @default.
- W3081629905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7460781" @default.
- W3081629905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32867820" @default.
- W3081629905 hasPublicationYear "2020" @default.
- W3081629905 type Work @default.
- W3081629905 sameAs 3081629905 @default.
- W3081629905 citedByCount "12" @default.
- W3081629905 countsByYear W30816299052021 @default.
- W3081629905 countsByYear W30816299052022 @default.
- W3081629905 countsByYear W30816299052023 @default.
- W3081629905 crossrefType "journal-article" @default.
- W3081629905 hasAuthorship W3081629905A5019737130 @default.
- W3081629905 hasAuthorship W3081629905A5039152252 @default.
- W3081629905 hasAuthorship W3081629905A5041084992 @default.
- W3081629905 hasAuthorship W3081629905A5065015794 @default.
- W3081629905 hasAuthorship W3081629905A5087956049 @default.
- W3081629905 hasBestOaLocation W30816299051 @default.
- W3081629905 hasConcept C104317684 @default.
- W3081629905 hasConcept C136449434 @default.
- W3081629905 hasConcept C16685009 @default.
- W3081629905 hasConcept C170493617 @default.
- W3081629905 hasConcept C196843134 @default.
- W3081629905 hasConcept C203014093 @default.
- W3081629905 hasConcept C203565725 @default.
- W3081629905 hasConcept C2775979320 @default.
- W3081629905 hasConcept C2776878037 @default.
- W3081629905 hasConcept C2776914184 @default.
- W3081629905 hasConcept C2779341262 @default.
- W3081629905 hasConcept C54166955 @default.
- W3081629905 hasConcept C55493867 @default.
- W3081629905 hasConcept C71924100 @default.
- W3081629905 hasConcept C86803240 @default.
- W3081629905 hasConcept C87073359 @default.
- W3081629905 hasConcept C8891405 @default.
- W3081629905 hasConcept C95444343 @default.
- W3081629905 hasConceptScore W3081629905C104317684 @default.
- W3081629905 hasConceptScore W3081629905C136449434 @default.
- W3081629905 hasConceptScore W3081629905C16685009 @default.
- W3081629905 hasConceptScore W3081629905C170493617 @default.
- W3081629905 hasConceptScore W3081629905C196843134 @default.
- W3081629905 hasConceptScore W3081629905C203014093 @default.
- W3081629905 hasConceptScore W3081629905C203565725 @default.
- W3081629905 hasConceptScore W3081629905C2775979320 @default.
- W3081629905 hasConceptScore W3081629905C2776878037 @default.
- W3081629905 hasConceptScore W3081629905C2776914184 @default.
- W3081629905 hasConceptScore W3081629905C2779341262 @default.
- W3081629905 hasConceptScore W3081629905C54166955 @default.
- W3081629905 hasConceptScore W3081629905C55493867 @default.
- W3081629905 hasConceptScore W3081629905C71924100 @default.
- W3081629905 hasConceptScore W3081629905C86803240 @default.
- W3081629905 hasConceptScore W3081629905C87073359 @default.
- W3081629905 hasConceptScore W3081629905C8891405 @default.
- W3081629905 hasConceptScore W3081629905C95444343 @default.
- W3081629905 hasFunder F4320311959 @default.
- W3081629905 hasFunder F4320337361 @default.
- W3081629905 hasFunder F4320337382 @default.
- W3081629905 hasIssue "1" @default.
- W3081629905 hasLocation W30816299051 @default.
- W3081629905 hasLocation W30816299052 @default.
- W3081629905 hasOpenAccess W3081629905 @default.
- W3081629905 hasPrimaryLocation W30816299051 @default.